Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2504746..2505272 | Replicon | chromosome |
| Accession | NZ_CP072539 | ||
| Organism | Escherichia coli O128ac:H12 strain AW1.7 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | J7886_RS12160 | Protein ID | WP_000323025.1 |
| Coordinates | 2504985..2505272 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | J7886_RS12155 | Protein ID | WP_000534858.1 |
| Coordinates | 2504746..2504985 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J7886_RS12135 (2500666) | 2500666..2502975 | - | 2310 | Protein_2387 | DmsA/YnfE/YnfF family dimethyl sulfoxide reductase | - |
| J7886_RS12140 (2503029) | 2503029..2503997 | - | 969 | WP_077898063.1 | IS5 family transposase | - |
| J7886_RS12145 (2504028) | 2504028..2504213 | - | 186 | Protein_2389 | FlxA-like family protein | - |
| J7886_RS12150 (2504416) | 2504416..2504721 | - | 306 | WP_001326990.1 | protein YdfV | - |
| J7886_RS12155 (2504746) | 2504746..2504985 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| J7886_RS12160 (2504985) | 2504985..2505272 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| J7886_RS12165 (2505344) | 2505344..2505499 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| J7886_RS12170 (2505716) | 2505716..2505967 | + | 252 | WP_000980994.1 | protein Rem | - |
| J7886_RS12175 (2506034) | 2506034..2506312 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| J7886_RS12180 (2506314) | 2506314..2507363 | + | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| J7886_RS12185 (2507377) | 2507377..2508129 | + | 753 | WP_001047135.1 | antitermination protein | - |
| J7886_RS12190 (2508407) | 2508407..2508496 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| J7886_RS12195 (2508551) | 2508551..2508763 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| J7886_RS12200 (2509064) | 2509064..2509279 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| J7886_RS25030 (2509643) | 2509643..2509813 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| J7886_RS12205 (2510033) | 2510033..2510248 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2489337..2564363 | 75026 | |
| - | flank | IS/Tn | - | - | 2503029..2503952 | 923 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T197995 WP_000323025.1 NZ_CP072539:2504985-2505272 [Escherichia coli O128ac:H12]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T197995 NZ_CP096839:c1934670-1934281 [Mycobacterium tuberculosis variant bovis]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT197995 WP_000534858.1 NZ_CP072539:2504746-2504985 [Escherichia coli O128ac:H12]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT197995 NZ_CP096839:c1934894-1934667 [Mycobacterium tuberculosis variant bovis]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|