197985

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1286388..1287055 Replicon chromosome
Accession NZ_CP072539
Organism Escherichia coli O128ac:H12 strain AW1.7

Toxin (Protein)


Gene name ypjF Uniprot ID A0A2I8SC83
Locus tag J7886_RS06075 Protein ID WP_054626383.1
Coordinates 1286388..1286717 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A2I8SA04
Locus tag J7886_RS06080 Protein ID WP_054626382.1
Coordinates 1286738..1287055 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J7886_RS06065 (1281444) 1281444..1286021 + 4578 Protein_1195 AIDA repeat-containing protein -
J7886_RS06075 (1286388) 1286388..1286717 - 330 WP_054626383.1 TA system toxin CbtA family protein Toxin
J7886_RS06080 (1286738) 1286738..1287055 - 318 WP_054626382.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
J7886_RS06085 (1287073) 1287073..1287294 - 222 WP_054626381.1 DUF987 domain-containing protein -
J7886_RS06090 (1287303) 1287303..1287779 - 477 WP_054626380.1 RadC family protein -
J7886_RS06095 (1287795) 1287795..1288253 - 459 WP_049606139.1 antirestriction protein -
J7886_RS06100 (1288337) 1288337..1288576 - 240 WP_054626379.1 DUF905 domain-containing protein -
J7886_RS06105 (1288676) 1288676..1289584 - 909 WP_064761968.1 Ivy family c-type lysozyme inhibitor -
J7886_RS06110 (1289653) 1289653..1289820 - 168 Protein_1203 DUF4339 domain-containing protein -
J7886_RS06115 (1289858) 1289858..1290553 - 696 WP_054626378.1 hypothetical protein -
J7886_RS06120 (1290780) 1290780..1291607 - 828 WP_054626377.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1274261..1316183 41922


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12324.29 Da        Isoelectric Point: 7.1642

>T197985 WP_054626383.1 NZ_CP072539:c1286717-1286388 [Escherichia coli O128ac:H12]
MKTLPATTPQAAKLCLPPVAVWQMLLTRLLETHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDRNGF
SWQEQTPYISVVDILRARRSTGLLKNNVK

Download         Length: 330 bp

>T197985 NZ_CP096839:1012293-1012727 [Mycobacterium tuberculosis variant bovis]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11741.53 Da        Isoelectric Point: 7.0161

>AT197985 WP_054626382.1 NZ_CP072539:c1287055-1286738 [Escherichia coli O128ac:H12]
MSKITWGLQRNITPHLGARLVQEGNRLHYLADRASITGKISDAECLKLDVAFPHFISQMELMLTTGEMNPCHAHCVILYH
NGFTCEADTLGSCGYVYVAVYPTQR

Download         Length: 318 bp

>AT197985 NZ_CP096839:1012108-1012287 [Mycobacterium tuberculosis variant bovis]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCAGGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8SC83

Antitoxin

Source ID Structure
AlphaFold DB A0A2I8SA04

References