Detailed information of TA system TA197983

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 1148683..1149266
• Replicon: chromosome
• Accession: NZ_CP072539
• Organism: Escherichia coli O128ac:H12 strain AW1.7

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: S1EZP4
• Locus tag: J7886_RS05390
• Protein ID: WP_000254738.1
• Coordinates: 1148931..1149266 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: S1P3W5
• Locus tag: J7886_RS05385
• Protein ID: WP_000581937.1
• Coordinates: 1148683..1148931 (+)
• Length: 83 a.a.

Genomic Context

Location: 1145022..1146323 (1302 bp)
Type: Others
Protein ID: WP_000046790.1

Location: 1146371..1148605 (2235 bp)
Type: Others
Protein ID: WP_000226815.1

Location: 1148683..1148931 (249 bp)
Type: Antitoxin
Protein ID: WP_000581937.1

Location: 1148931..1149266 (336 bp)
Type: Toxin
Protein ID: WP_000254738.1

Location: 1149337..1150128 (792 bp)
Type: Others
Protein ID: WP_001071648.1

Location: 1150356..1151993 (1638 bp)
Type: Others
Protein ID: WP_000210878.1

Location: 1152081..1153379 (1299 bp)
Type: Others
Protein ID: WP_000036723.1

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Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J7886_RS05375 (1145022)	1145022..1146323	+	1302	WP_000046790.1	23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD	-
J7886_RS05380 (1146371)	1146371..1148605	+	2235	WP_000226815.1	GTP pyrophosphokinase	-
J7886_RS05385 (1148683)	1148683..1148931	+	249	WP_000581937.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
J7886_RS05390 (1148931)	1148931..1149266	+	336	WP_000254738.1	endoribonuclease MazF	Toxin
J7886_RS05395 (1149337)	1149337..1150128	+	792	WP_001071648.1	nucleoside triphosphate pyrophosphohydrolase	-
J7886_RS05400 (1150356)	1150356..1151993	+	1638	WP_000210878.1	CTP synthase (glutamine hydrolyzing)	-
J7886_RS05405 (1152081)	1152081..1153379	+	1299	WP_000036723.1	phosphopyruvate hydratase	-

Associated MGEs

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MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
No matching records found

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (10-109)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12098.04 Da
• Isoelectric Point: 8.2618

>T197983 WP_000254738.1 NZ_CP072539:1148931-1149266 [Escherichia coli O128ac:H12]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG

Nucleotide

• Length: 336 bp

>T197983 NZ_CP096839:c754206-753769 [Mycobacterium tuberculosis variant bovis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9355.74 Da
• Isoelectric Point: 4.4665

>AT197983 WP_000581937.1 NZ_CP072539:1148683-1148931 [Escherichia coli O128ac:H12]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW

Nucleotide

• Length: 249 bp

>AT197983 NZ_CP096839:c754457-754203 [Mycobacterium tuberculosis variant bovis]
ATGAGCATGCGTCTGGCGCATCGGCTCCAGATCCTGCTCGACGACGAGTGCCACCGCCGCATCACCGCGGTGGCGCGCGA
GCGAGGCGTCCCGGTCGCAACCGTCGTGCGTGAGGCCATTGATCGAGGCCTCGTCAGCCCCGCCGGTCGCCGCAAGTCCG
CGGGCAGGCGCCTGCTCGACGCCGCCGACATGTCCGTTCCCGAGCCGCGGGAGCTGAAGCAGGAACTCGAGGCCCTCCGG
GCGCGCCGCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Toxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
No matching records found

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Antitoxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
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Structures

Toxin

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• PDB: 1UB4
• PDB: 5CQX
• PDB: 5CK9
• PDB: 5CKH
• PDB: 5CO7
• PDB: 3NFC
• PDB: 5CR2
• PDB: 5CKB
• PDB: 5CQY
• PDB: 5CKD
• PDB: 5CKE
• PDB: 5CKF

Antitoxin

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• PDB: 1UB4
• PDB: 5CQX
• PDB: 5CQY
• PDB: 1MVF
• PDB: 2MRN
• PDB: 2MRU
• AlphaFold DB: A0A7U9LMB4