Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 445424..446055 Replicon chromosome
Accession NZ_CP072539
Organism Escherichia coli O128ac:H12 strain AW1.7

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag J7886_RS01885 Protein ID WP_001259385.1
Coordinates 445424..445699 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag J7886_RS01890 Protein ID WP_000593555.1
Coordinates 445696..446055 (+) Length 120 a.a.

Genomic Context

J7886_RS01870J7886_RS01875J7886_RS01880J7886_RS01885J7886_RS01890J7886_RS01895J7886_RS01900J7886_RS01905J7886_RS01910J7886_RS01915
Location: 440428..441495 (1068 bp)
Type: Others
Protein ID: WP_000361470.1
Location: 441492..444227 (2736 bp)
Type: Others
Protein ID: WP_000149123.1
Location: 444227..445351 (1125 bp)
Type: Others
Protein ID: WP_001488398.1
Location: 445424..445699 (276 bp)
Type: Toxin
Protein ID: WP_001259385.1
Location: 445696..446055 (360 bp)
Type: Antitoxin
Protein ID: WP_000593555.1
Location: 446175..446576 (402 bp)
Type: Others
Protein ID: WP_001190062.1
Location: 446582..447388 (807 bp)
Type: Others
Protein ID: WP_054626010.1
Location: 447385..448149 (765 bp)
Type: Others
Protein ID: WP_001136236.1
Location: 448149..448982 (834 bp)
Type: Others
Protein ID: WP_001008963.1
Location: 448979..449923 (945 bp)
Type: Others
Protein ID: WP_000947068.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
J7886_RS01870 (440428)440428..441495+1068WP_000361470.1HlyD family secretion protein-
J7886_RS01875 (441492)441492..444227+2736WP_000149123.1ribosome-associated ATPase/putative transporter RbbA-
J7886_RS01880 (444227)444227..445351+1125WP_001488398.1ABC transporter permease-
J7886_RS01885 (445424)445424..445699+276WP_001259385.1type II toxin-antitoxin system HicA family toxinToxin
J7886_RS01890 (445696)445696..446055+360WP_000593555.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
J7886_RS01895 (446175)446175..446576-402WP_001190062.1nickel-responsive transcriptional regulator NikR-
J7886_RS01900 (446582)446582..447388-807WP_054626010.1nickel import ATP-binding protein NikE-
J7886_RS01905 (447385)447385..448149-765WP_001136236.1nickel import ATP-binding protein NikD-
J7886_RS01910 (448149)448149..448982-834WP_001008963.1nickel ABC transporter permease subunit NikC-
J7886_RS01915 (448979)448979..449923-945WP_000947068.1nickel ABC transporter permease subunit NikB-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegrative and Conjugative Element--374705..44738872683


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T197978 WP_001259385.1 NZ_CP072539:445424-445699 [Escherichia coli O128ac:H12]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T197978 NZ_CP096839:714575-714970 [Mycobacterium tuberculosis variant bovis]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT197978 WP_000593555.1 NZ_CP072539:445696-446055 [Escherichia coli O128ac:H12]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT197978 NZ_CP096839:714321-714575 [Mycobacterium tuberculosis variant bovis]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A4P7TTW8

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A7U9LKZ6

References