Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | BrnTA/BrnT-BrnA |
| Location | 52155..52743 | Replicon | plasmid pDETAB5 |
| Accession | NZ_CP072528 | ||
| Organism | Acinetobacter baumannii strain DETAB-E227 | ||
Toxin (Protein)
| Gene name | brnT | Uniprot ID | N8SM64 |
| Locus tag | J7D37_RS18710 | Protein ID | WP_000438825.1 |
| Coordinates | 52155..52442 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | brnA | Uniprot ID | D3JXQ4 |
| Locus tag | J7D37_RS18715 | Protein ID | WP_004728120.1 |
| Coordinates | 52429..52743 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J7D37_RS18670 (J7D37_18670) | 47235..47711 | - | 477 | WP_074163966.1 | AraC family ligand binding domain-containing protein | - |
| J7D37_RS18675 (J7D37_18675) | 47885..48591 | - | 707 | Protein_42 | IS1 family transposase | - |
| J7D37_RS18680 (J7D37_18680) | 48682..49524 | - | 843 | WP_002002480.1 | carbapenem-hydrolyzing class D beta-lactamase OXA-58 | - |
| J7D37_RS18685 (J7D37_18685) | 49605..49973 | + | 369 | Protein_44 | IS1-like element ISAba3 family transposase | - |
| J7D37_RS18690 (J7D37_18690) | 50124..50543 | + | 420 | WP_001180106.1 | SMI1/KNR4 family protein | - |
| J7D37_RS18695 (J7D37_18695) | 50623..50904 | - | 282 | WP_000985609.1 | putative addiction module antidote protein | - |
| J7D37_RS18700 (J7D37_18700) | 50905..51207 | - | 303 | WP_000286964.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| J7D37_RS18705 (J7D37_18705) | 51356..51886 | + | 531 | WP_000172759.1 | hypothetical protein | - |
| J7D37_RS18710 (J7D37_18710) | 52155..52442 | + | 288 | WP_000438825.1 | BrnT family toxin | Toxin |
| J7D37_RS18715 (J7D37_18715) | 52429..52743 | + | 315 | WP_004728120.1 | BrnA antitoxin family protein | Antitoxin |
| J7D37_RS18720 (J7D37_18720) | 52804..53574 | - | 771 | WP_032073134.1 | hypothetical protein | - |
| J7D37_RS18725 (J7D37_18725) | 53633..53971 | + | 339 | WP_032073153.1 | hypothetical protein | - |
| J7D37_RS18730 (J7D37_18730) | 54099..54803 | - | 705 | WP_001067784.1 | IS6-like element IS1006 family transposase | - |
| J7D37_RS18735 (J7D37_18735) | 54867..55697 | + | 831 | Protein_54 | IS91-like element ISVsa3 family transposase | - |
| J7D37_RS18740 (J7D37_18740) | 55933..56175 | - | 243 | Protein_55 | phosphoglucosamine mutase | - |
| J7D37_RS18745 (J7D37_18745) | 56262..57077 | - | 816 | WP_001043260.1 | sulfonamide-resistant dihydropteroate synthase Sul2 | - |
| J7D37_RS18750 (J7D37_18750) | 57167..57514 | + | 348 | Protein_57 | IS4 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | aac(3)-IId / blaOXA-58 / sul2 / msr(E) / mph(E) / blaNDM-1 | - | 1..97035 | 97035 | |
| - | inside | IScluster/Tn | aac(3)-IId / blaOXA-58 / sul2 | - | 38895..58297 | 19402 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11304.70 Da Isoelectric Point: 5.6205
>T197974 WP_000438825.1 NZ_CP072528:52155-52442 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTDGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTDGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG
Download Length: 288 bp
>T197974 NZ_CP096839:c693141-692749 [Mycobacterium tuberculosis variant bovis]
GTGAACGTACGGCGCGCCCTCGCCGACACATCCGTTTTCATTGGCATCGAGGCGACACGATTCGACCCGGACCGGTTTGC
GGGATACGAATGGGGCGTCTCGGTAGTCACACTCGGCGAGCTGCGGCTCGGGGTGTTGCAAGCCTCCGGCCCCGAGGCCG
CCGCACGTCGGCTCTCCACCTACCAGCTTGCGCAACGGTTCGAACCACTAGGCATCGACGAGGCGGTCTCCGAAGCATGG
GCATTACTGGTGTCCAAGCTGCGCGCCGCCAAACTGCGCGTGCCGATCAACGACAGCTGGATTGCGGCCACAGCCGTGGC
GCACGGCATTGCGATCCTGACCCAAGACAACGACTACGCCGCCATGCCCGACGTCGAGGTCATAACGATCTGA
GTGAACGTACGGCGCGCCCTCGCCGACACATCCGTTTTCATTGGCATCGAGGCGACACGATTCGACCCGGACCGGTTTGC
GGGATACGAATGGGGCGTCTCGGTAGTCACACTCGGCGAGCTGCGGCTCGGGGTGTTGCAAGCCTCCGGCCCCGAGGCCG
CCGCACGTCGGCTCTCCACCTACCAGCTTGCGCAACGGTTCGAACCACTAGGCATCGACGAGGCGGTCTCCGAAGCATGG
GCATTACTGGTGTCCAAGCTGCGCGCCGCCAAACTGCGCGTGCCGATCAACGACAGCTGGATTGCGGCCACAGCCGTGGC
GCACGGCATTGCGATCCTGACCCAAGACAACGACTACGCCGCCATGCCCGACGTCGAGGTCATAACGATCTGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12200.86 Da Isoelectric Point: 8.4628
>AT197974 WP_004728120.1 NZ_CP072528:52429-52743 [Acinetobacter baumannii]
MSMVRYSRKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSSAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ
MSMVRYSRKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSSAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ
Download Length: 315 bp
>AT197974 NZ_CP096839:c693395-693138 [Mycobacterium tuberculosis variant bovis]
ATGTCTGCTACGATACCCGCTCGCGATCTTCGCAACCACACCGCCGAGGTACTGCGGCGAGTTGCCGCCGGCGAGGAAAT
CGAGGTGCTCAAGGACAATCGCCCCGTAGCGCGCATCGTTCCGCTCAAGCGGCGCCGCCAATGGTTGCCAGCTGCCGAGG
TGATCGGCGAACTGGTGCGCTTGGGCCCCGATACCACCAATCTGGGCGAGGAGCTGCGAGAGACGCTGACGCAAACCACG
GACGATGTGCGGTGGTGA
ATGTCTGCTACGATACCCGCTCGCGATCTTCGCAACCACACCGCCGAGGTACTGCGGCGAGTTGCCGCCGGCGAGGAAAT
CGAGGTGCTCAAGGACAATCGCCCCGTAGCGCGCATCGTTCCGCTCAAGCGGCGCCGCCAATGGTTGCCAGCTGCCGAGG
TGATCGGCGAACTGGTGCGCTTGGGCCCCGATACCACCAATCTGGGCGAGGAGCTGCGAGAGACGCTGACGCAAACCACG
GACGATGTGCGGTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0A8TVQ4 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0A8TRI9 |