Detailed information of TA system TA197972

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 3269711..3270364
• Replicon: chromosome
• Accession: NZ_CP072526
• Organism: Acinetobacter baumannii strain DETAB-E227

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: J7D37_RS15525
• Protein ID: WP_000607096.1
• Coordinates: 3269711..3270100 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: J7D37_RS15530
• Protein ID: WP_001288210.1
• Coordinates: 3270107..3270364 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J7D37_RS15510 (J7D37_15510)	3264829..3267024	-	2196	WP_001158905.1	TRAP transporter large permease subunit	-
J7D37_RS15515 (J7D37_15515)	3267212..3267778	-	567	Protein_3033	rhombosortase	-
J7D37_RS15520 (J7D37_15520)	3267856..3268941	-	1086	WP_038347743.1	hypothetical protein	-
J7D37_RS15525 (J7D37_15525)	3269711..3270100	-	390	WP_000607096.1	hypothetical protein	Toxin
J7D37_RS15530 (J7D37_15530)	3270107..3270364	-	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
J7D37_RS15535 (J7D37_15535)	3270552..3271724	+	1173	WP_038347742.1	acyl-CoA dehydrogenase family protein	-
J7D37_RS15540 (J7D37_15540)	3271773..3273263	-	1491	WP_000415133.1	NAD(P)/FAD-dependent oxidoreductase	-
J7D37_RS15545 (J7D37_15545)	3273445..3273822	-	378	WP_001216380.1	50S ribosomal protein L17	-
J7D37_RS15550 (J7D37_15550)	3273841..3274848	-	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15583.80 Da
• Isoelectric Point: 10.4637

>T197972 WP_000607096.1 NZ_CP072526:c3270100-3269711 [Acinetobacter baumannii]
MINHSNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLH

Nucleotide

• Length: 390 bp

>T197972 NZ_CP096839:c445412-444819 [Mycobacterium tuberculosis variant bovis]
GTGAAGCGGCTCGATCTGGTCGCCGGGCCCAACGGCGCCGGCAAGTCGACGTTCGTCGCCCTCACGCTGGCGCCCTTGCT
GCCCGGCATCGTCTTCGTCAACGCCGACGAAATCGCCAAACAACGCTGGCCCGACGACCCAACATCGCACGCCTACCAGG
CGGCGCAGGTCGCCGCCGACACCCGCGCGAGGCTCATCGACTTGGGCCGGCCGTTCATTGCCGAGACGGTGTTCTCGCAC
CCATCGAAGCTCGAGCTCATCCGCACCGCGCGCACGGCCGGCTACACCGTCGTACTGCACGTGTTGGTTATCCCCGAAGG
CCTGGCGGTCGAGCGCGTCAGGCATCGCGTCGCCGCGGGCGGCCACGATGTGCCGGAGACCAAGATCCGCGAGCGTCACC
GCCGGCTGGCCGAGCTTGTCGCCCAGGCCATCACGCTGGCCGACGGCGCCACCGTCTATGACAACAGCCGGCTCGCGGGC
CCGCGGATCGTCGCTCAGTTCAGCGGGGGTGGCATCATCGGGCGCGCATGCTGGCCTTCGTGGACGCCGCCACCCTTGAT
GTCACGCTGGAGTAACAGGCCTGAGACGGCGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT197972 WP_001288210.1 NZ_CP072526:c3270364-3270107 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT197972 NZ_CP096839:c445830-445441 [Mycobacterium tuberculosis variant bovis]
GTGCCCAAAGCCGTCGACCGCGTCACGCGCGTCGCCGCGGATCTGGTGGACAGCGCGGCGGCCGAGGGTGCTCGTCAGAG
CCGTTCGGCCAAGCAGCAGCTCGACCACTGGGCCCGCGTCGGTCGGGCGGTGTCGAACCAGCACACGGCGTCGCGGCGCC
GCGTGGAAGCTGCGCTCGCGGGGCATCTGCCGATGACGGACCTGACGCTGGAGGAGGGCGTGGTGTTCAACGCCGAGATC
TCCGCAGCTATCGAGGAGCGCCTGTCGCGAACCAACTACGGCGACGTGCTCGCCGCGCAGGGCATCACCACGGTCGCCCT
GAACGACGCGGGCGACATCGTCGAGCACCGGCCAGACGGCACCTCGGTCGTGCTGGCAGCCACGCCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7