Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1592986..1593598 Replicon chromosome
Accession NZ_CP072523
Organism Streptococcus pyogenes strain SHZ-1

Toxin (Protein)


Gene name parE Uniprot ID A0A4Z2JY48
Locus tag J7S31_RS08130 Protein ID WP_002982731.1
Coordinates 1593263..1593598 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A5S4TJ53
Locus tag J7S31_RS08125 Protein ID WP_011055007.1
Coordinates 1592986..1593273 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J7S31_RS08100 (J7S31_08075) 1588178..1589161 - 984 WP_011055003.1 tagatose-bisphosphate aldolase -
J7S31_RS08105 (J7S31_08080) 1589165..1590094 - 930 WP_011055004.1 tagatose-6-phosphate kinase -
J7S31_RS08110 (J7S31_08085) 1590140..1590655 - 516 WP_011055005.1 galactose-6-phosphate isomerase subunit LacB -
J7S31_RS08115 (J7S31_08090) 1590690..1591118 - 429 WP_002982747.1 galactose-6-phosphate isomerase subunit LacA -
J7S31_RS08120 (J7S31_08095) 1591563..1592336 + 774 WP_011055006.1 DeoR/GlpR family DNA-binding transcription regulator -
J7S31_RS08125 (J7S31_08100) 1592986..1593273 + 288 WP_011055007.1 hypothetical protein Antitoxin
J7S31_RS08130 (J7S31_08105) 1593263..1593598 + 336 WP_002982731.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J7S31_RS08135 (J7S31_08110) 1593722..1594736 + 1015 Protein_1546 site-specific integrase -
J7S31_RS08140 (J7S31_08115) 1594868..1595260 - 393 WP_002982716.1 30S ribosomal protein S9 -
J7S31_RS08145 (J7S31_08120) 1595281..1595727 - 447 WP_002982710.1 50S ribosomal protein L13 -
J7S31_RS08150 (J7S31_08125) 1595945..1596151 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
J7S31_RS08155 (J7S31_08130) 1596148..1596846 - 699 WP_011055008.1 hypothetical protein -
J7S31_RS08160 (J7S31_08135) 1596973..1597833 - 861 WP_011055009.1 DegV family protein -
J7S31_RS08165 (J7S31_08140) 1597930..1598448 - 519 WP_011055010.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13145.88 Da        Isoelectric Point: 5.2144

>T197965 WP_002982731.1 NZ_CP072523:1593263-1593598 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

>T197965 NZ_CP096837:c4247609-4247259 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10964.59 Da        Isoelectric Point: 5.2318

>AT197965 WP_011055007.1 NZ_CP072523:1592986-1593273 [Streptococcus pyogenes]
MTTVKKNRTVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp

>AT197965 NZ_CP096837:c4247854-4247603 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Z2JY48

Antitoxin

Source ID Structure
AlphaFold DB A0A5S4TJ53

References