Detailed information of TA system TA197964

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbE-relB/ParE-YafN
• Location: 2858512..2859031
• Replicon: chromosome
• Accession: NZ_CP072521
• Organism: Burkholderia seminalis strain 869T2

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: -
• Locus tag: DT99_RS29280
• Protein ID: WP_080287803.1
• Coordinates: 2858512..2858793 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8A8D9S1
• Locus tag: DT99_RS29285
• Protein ID: WP_034187669.1
• Coordinates: 2858783..2859031 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DT99_RS29260 (DT99_029260)	2854170..2854868	-	699	WP_034187673.1	MgtC/SapB family protein	-
DT99_RS29265 (DT99_029265)	2854984..2856093	+	1110	WP_034187672.1	AGE family epimerase/isomerase	-
DT99_RS29270 (DT99_029270)	2856066..2857685	-	1620	WP_034187671.1	methyl-accepting chemotaxis protein	-
DT99_RS29275 (DT99_029275)	2857957..2858400	+	444	WP_034187670.1	PaaI family thioesterase	-
DT99_RS29280 (DT99_029280)	2858512..2858793	-	282	WP_080287803.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DT99_RS29285 (DT99_029285)	2858783..2859031	-	249	WP_034187669.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DT99_RS29290 (DT99_029290)	2859169..2860227	-	1059	WP_034187853.1	CaiB/BaiF CoA-transferase family protein	-
DT99_RS29295 (DT99_029295)	2860387..2861577	-	1191	WP_034187668.1	2-methylaconitate cis-trans isomerase PrpF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (12-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10850.62 Da
• Isoelectric Point: 10.8406

>T197964 WP_080287803.1 NZ_CP072521:c2858793-2858512 [Burkholderia seminalis]
MTFERAFLEPELREWKKLDRTGRDRFKAGLAERIEHPRVPPARLHGHPDRYKIKLRGVGYRLVYEVRDSEVVVLVVAVGR
REGDAVNLAAMKR

Nucleotide

• Length: 282 bp

>T197964 NZ_CP096837:4138165-4138506 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACTCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCACCCCCCCGCCGCCAAAGAGAGCGAA
CTGATGCAGTCGCTTCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAGAAGCAGGTGCAGGAATTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8963.32 Da
• Isoelectric Point: 5.6567

>AT197964 WP_034187669.1 NZ_CP072521:c2859031-2858783 [Burkholderia seminalis]
MPHTMLASVTASVSALKRNPLGTVAAGEGFPVAILNHNEPAFYCIPAKTWEAMVERLEDIEDNALADSRTKERVVKVKLN
DL

Nucleotide

• Length: 249 bp

>AT197964 NZ_CP096837:c4138170-4138094 [Escherichia coli]
AGTCATAACTGCTATTCTCCATAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin

• AlphaFold DB: A0A8A8D9S1