Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
Location | 1929222..1930972 | Replicon | chromosome |
Accession | NZ_CP072521 | ||
Organism | Burkholderia seminalis strain 869T2 |
Toxin (Protein)
Gene name | doc | Uniprot ID | - |
Locus tag | DT99_RS25155 | Protein ID | WP_034189896.1 |
Coordinates | 1930076..1930972 (-) | Length | 299 a.a. |
Antitoxin (Protein)
Gene name | phd | Uniprot ID | - |
Locus tag | DT99_RS25150 | Protein ID | WP_034189895.1 |
Coordinates | 1929222..1930079 (-) | Length | 286 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
DT99_RS25130 (DT99_025130) | 1924397..1925887 | - | 1491 | WP_034189891.1 | aldehyde dehydrogenase | - |
DT99_RS25135 (DT99_025135) | 1925960..1926775 | - | 816 | WP_034189892.1 | aspartate dehydrogenase | - |
DT99_RS25140 (DT99_025140) | 1926768..1928435 | - | 1668 | WP_034189893.1 | thiamine pyrophosphate-binding protein | - |
DT99_RS25145 (DT99_025145) | 1928428..1929225 | - | 798 | WP_034189894.1 | SDR family oxidoreductase | - |
DT99_RS25150 (DT99_025150) | 1929222..1930079 | - | 858 | WP_034189895.1 | IclR family transcriptional regulator | Antitoxin |
DT99_RS25155 (DT99_025155) | 1930076..1930972 | - | 897 | WP_034189896.1 | alpha/beta fold hydrolase | Toxin |
DT99_RS25160 (DT99_025160) | 1930991..1931518 | - | 528 | WP_034189947.1 | cupin domain-containing protein | - |
DT99_RS25165 (DT99_025165) | 1931548..1932318 | - | 771 | WP_034189897.1 | SDR family oxidoreductase | - |
DT99_RS25170 (DT99_025170) | 1932311..1933381 | - | 1071 | WP_034189898.1 | aromatic ring-hydroxylating dioxygenase subunit alpha | - |
DT99_RS25175 (DT99_025175) | 1933436..1933747 | - | 312 | WP_034189899.1 | hypothetical protein | - |
DT99_RS25180 (DT99_025180) | 1933749..1934066 | - | 318 | WP_006489883.1 | non-heme iron oxygenase ferredoxin subunit | - |
DT99_RS25185 (DT99_025185) | 1934513..1935592 | + | 1080 | WP_034189900.1 | porin | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 299 a.a. Molecular weight: 30504.72 Da Isoelectric Point: 8.0700
>T197961 WP_034189896.1 NZ_CP072521:c1930972-1930076 [Burkholderia seminalis]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGASPDAADYAASLNAWLEALGIERCVLVGHSLGAIVAGGLARAVPARIAGLLLVSPAGGYGSAPADTR
DARRDARLAMLAALGPAGLAEQRSGNMLSGFANEEAKAWVRWNMARIVPAGYAQATHLLANADLATDLAGFRGRTAVAVG
AHDAITPPAACERIAAAAHVALQVIPQAGHAGYVEAPAVYSALIDGFCRQCDPQRGLA
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGASPDAADYAASLNAWLEALGIERCVLVGHSLGAIVAGGLARAVPARIAGLLLVSPAGGYGSAPADTR
DARRDARLAMLAALGPAGLAEQRSGNMLSGFANEEAKAWVRWNMARIVPAGYAQATHLLANADLATDLAGFRGRTAVAVG
AHDAITPPAACERIAAAAHVALQVIPQAGHAGYVEAPAVYSALIDGFCRQCDPQRGLA
Download Length: 897 bp
>T197961 NZ_CP096837:3539446-3539664 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 286 a.a. Molecular weight: 31305.85 Da Isoelectric Point: 7.1325
>AT197961 WP_034189895.1 NZ_CP072521:c1930079-1929222 [Burkholderia seminalis]
MSEPLQRPASEHAKADANYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGALTRMTSATPETVDALYDVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR
MSEPLQRPASEHAKADANYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGALTRMTSATPETVDALYDVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR
Download Length: 858 bp
>AT197961 NZ_CP096837:3539046-3539420 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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