197961

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1929222..1930972 Replicon chromosome
Accession NZ_CP072521
Organism Burkholderia seminalis strain 869T2

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag DT99_RS25155 Protein ID WP_034189896.1
Coordinates 1930076..1930972 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag DT99_RS25150 Protein ID WP_034189895.1
Coordinates 1929222..1930079 (-) Length 286 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DT99_RS25130 (DT99_025130) 1924397..1925887 - 1491 WP_034189891.1 aldehyde dehydrogenase -
DT99_RS25135 (DT99_025135) 1925960..1926775 - 816 WP_034189892.1 aspartate dehydrogenase -
DT99_RS25140 (DT99_025140) 1926768..1928435 - 1668 WP_034189893.1 thiamine pyrophosphate-binding protein -
DT99_RS25145 (DT99_025145) 1928428..1929225 - 798 WP_034189894.1 SDR family oxidoreductase -
DT99_RS25150 (DT99_025150) 1929222..1930079 - 858 WP_034189895.1 IclR family transcriptional regulator Antitoxin
DT99_RS25155 (DT99_025155) 1930076..1930972 - 897 WP_034189896.1 alpha/beta fold hydrolase Toxin
DT99_RS25160 (DT99_025160) 1930991..1931518 - 528 WP_034189947.1 cupin domain-containing protein -
DT99_RS25165 (DT99_025165) 1931548..1932318 - 771 WP_034189897.1 SDR family oxidoreductase -
DT99_RS25170 (DT99_025170) 1932311..1933381 - 1071 WP_034189898.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
DT99_RS25175 (DT99_025175) 1933436..1933747 - 312 WP_034189899.1 hypothetical protein -
DT99_RS25180 (DT99_025180) 1933749..1934066 - 318 WP_006489883.1 non-heme iron oxygenase ferredoxin subunit -
DT99_RS25185 (DT99_025185) 1934513..1935592 + 1080 WP_034189900.1 porin -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(51-279)

Antitoxin

(24-72)


Sequences


Toxin        


Download         Length: 299 a.a.        Molecular weight: 30504.72 Da        Isoelectric Point: 8.0700

>T197961 WP_034189896.1 NZ_CP072521:c1930972-1930076 [Burkholderia seminalis]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGASPDAADYAASLNAWLEALGIERCVLVGHSLGAIVAGGLARAVPARIAGLLLVSPAGGYGSAPADTR
DARRDARLAMLAALGPAGLAEQRSGNMLSGFANEEAKAWVRWNMARIVPAGYAQATHLLANADLATDLAGFRGRTAVAVG
AHDAITPPAACERIAAAAHVALQVIPQAGHAGYVEAPAVYSALIDGFCRQCDPQRGLA

Download         Length: 897 bp

>T197961 NZ_CP096837:3539446-3539664 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31305.85 Da        Isoelectric Point: 7.1325

>AT197961 WP_034189895.1 NZ_CP072521:c1930079-1929222 [Burkholderia seminalis]
MSEPLQRPASEHAKADANYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGALTRMTSATPETVDALYDVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT197961 NZ_CP096837:3539046-3539420 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References