Detailed information of TA system TA197954

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 4741220..4741806
• Replicon: chromosome
• Accession: NZ_CP072515
• Organism: Klebsiella quasipneumoniae strain 3Z-5L

Toxin (Protein)

• Gene name: doc
• Uniprot ID: W8VD46
• Locus tag: J6325_RS22970
• Protein ID: WP_002920800.1
• Coordinates: 4741220..4741588 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: J6325_RS22975
• Protein ID: WP_040221757.1
• Coordinates: 4741585..4741806 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6325_RS22950 (4736647)	4736647..4737717	-	1071	WP_017899977.1	sn-glycerol-3-phosphate import ATP-binding protein UgpC	-
J6325_RS22955 (4737719)	4737719..4738564	-	846	WP_004202115.1	sn-glycerol-3-phosphate ABC transporter permease UgpE	-
J6325_RS22960 (4738561)	4738561..4739448	-	888	WP_002920792.1	sn-glycerol-3-phosphate ABC transporter permease UgpA	-
J6325_RS22965 (4739555)	4739555..4740871	-	1317	WP_004174008.1	sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB	-
J6325_RS22970 (4741220)	4741220..4741588	-	369	WP_002920800.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
J6325_RS22975 (4741585)	4741585..4741806	-	222	WP_040221757.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
J6325_RS22980 (4741970)	4741970..4742683	-	714	WP_004145133.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF	-
J6325_RS22985 (4742685)	4742685..4743452	-	768	WP_002920803.1	high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG	-
J6325_RS22990 (4743449)	4743449..4744726	-	1278	WP_004202111.1	branched chain amino acid ABC transporter permease LivM	-
J6325_RS22995 (4744723)	4744723..4745649	-	927	WP_002920807.1	high-affinity branched-chain amino acid ABC transporter permease LivH	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4735910..4744726	8816

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (13-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-51)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13552.92 Da
• Isoelectric Point: 8.6410

>T197954 WP_002920800.1 NZ_CP072515:c4741588-4741220 [Klebsiella quasipneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Nucleotide

• Length: 369 bp

>T197954 NZ_CP096837:883448-883855 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8133.12 Da
• Isoelectric Point: 4.7769

>AT197954 WP_040221757.1 NZ_CP072515:c4741806-4741585 [Klebsiella quasipneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARIDDEFAAIMAVHGDEIRELADK

Nucleotide

• Length: 222 bp

>AT197954 NZ_CP096837:883201-883467 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A0H3GUD1