Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4289377..4290034 Replicon chromosome
Accession NZ_CP072515
Organism Klebsiella quasipneumoniae strain 3Z-5L

Toxin (Protein)


Gene name cptA Uniprot ID A0A2A5MNX1
Locus tag J6325_RS20635 Protein ID WP_004205323.1
Coordinates 4289377..4289787 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag J6325_RS20640 Protein ID WP_002916312.1
Coordinates 4289768..4290034 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6325_RS20615 (4285377) 4285377..4287110 - 1734 WP_004205327.1 single-stranded-DNA-specific exonuclease RecJ -
J6325_RS20620 (4287116) 4287116..4287829 - 714 WP_004205326.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
J6325_RS20625 (4287852) 4287852..4288748 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
J6325_RS20630 (4288849) 4288849..4289370 + 522 WP_109938288.1 flavodoxin FldB -
J6325_RS20635 (4289377) 4289377..4289787 - 411 WP_004205323.1 protein YgfX Toxin
J6325_RS20640 (4289768) 4289768..4290034 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
J6325_RS20645 (4290280) 4290280..4291263 + 984 WP_017899798.1 tRNA-modifying protein YgfZ -
J6325_RS20650 (4291362) 4291362..4292021 - 660 WP_004205319.1 hemolysin III family protein -
J6325_RS20655 (4292184) 4292184..4292495 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
J6325_RS20660 (4292546) 4292546..4293274 + 729 WP_004205316.1 MurR/RpiR family transcriptional regulator -
J6325_RS20665 (4293393) 4293393..4294826 + 1434 WP_004205314.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T197953 WP_004205323.1 NZ_CP072515:c4289787-4289377 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
DWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T197953 NZ_CP096837:c639693-639229 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGATGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT197953 WP_002916312.1 NZ_CP072515:c4290034-4289768 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT197953 NZ_CP096837:c640028-639693 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCTTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAAATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A5MNX1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References