Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3516747..3518539 Replicon chromosome
Accession NZ_CP072515
Organism Klebsiella quasipneumoniae strain 3Z-5L

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag J6325_RS16930 Protein ID WP_109938479.1
Coordinates 3516747..3518096 (+) Length 450 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag J6325_RS16935 Protein ID WP_064178387.1
Coordinates 3518093..3518539 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6325_RS16905 (3512163) 3512163..3513095 - 933 WP_004201619.1 tRNA dihydrouridine(16) synthase DusC -
J6325_RS16910 (3513453) 3513453..3513857 + 405 WP_004201620.1 CidA/LrgA family protein -
J6325_RS16915 (3513847) 3513847..3514542 + 696 WP_004201621.1 CidB/LrgB family autolysis modulator -
J6325_RS16920 (3514671) 3514671..3515555 + 885 WP_049093651.1 cytidine deaminase -
J6325_RS16925 (3515901) 3515901..3516632 + 732 WP_008804033.1 outer membrane permeability protein SanA -
J6325_RS16930 (3516747) 3516747..3518096 + 1350 WP_109938479.1 HipA domain-containing protein Toxin
J6325_RS16935 (3518093) 3518093..3518539 + 447 WP_064178387.1 helix-turn-helix transcriptional regulator Antitoxin
J6325_RS16940 (3518581) 3518581..3519591 - 1011 WP_002912871.1 galactose/methyl galactoside ABC transporter permease MglC -
J6325_RS16945 (3519607) 3519607..3521127 - 1521 WP_004201625.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
J6325_RS16950 (3521246) 3521246..3522244 - 999 WP_004201626.1 galactose/glucose ABC transporter substrate-binding protein MglB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-410)

Antitoxin

Cro/C1-type helix-turn-helix domain

(78-132)


Sequences

Toxin        


Download         Length: 450 a.a.        Molecular weight: 51080.97 Da        Isoelectric Point: 4.8038

>T197952 WP_109938479.1 NZ_CP072515:3516747-3518096 [Klebsiella quasipneumoniae]
METLTVQAFLNAEWQDIALIKFPGSEQGDWFTTQIDYLTDYAIDFLERDDYHAVSLNHPVSLYFEDHGNPGWLRFIDDII
PSGASRRYWVNFLDISELPQGQQNFILLKFGTMSPVGNLRIKDSVPDWDSLASSKTFSVTDVMNRASDFLDYAQERGAAA
GGATGAGGEAPKLLLRCSKRQEIWIDTWQNEPGSDDLYYLVKYPRGSRSEVDCNILRAEFHYYHELTTMGFSTIPVDNMR
LEEGLHYPSLWLPRFDIRRDGDGRIMRLGMESVYSLLQKAPATILDHETTLRILIEKITSSHMVRVQNYRFDVQGFIIDW
VRRDLLNIIFGNSDNHGRNTAFMKADNEITLAPIYDFAPMKADPEGIPRTMKWSLACESGGEYNFGAIAQALAEWIAPDT
LLNALRETASQLIDLPSRLKARGVPVQILEMPSIGFKFIPDKLARWGLL

Download         Length: 1350 bp

>T197952 NZ_CP096837:205055-205162 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAACGGAAGTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16510.20 Da        Isoelectric Point: 10.5137

>AT197952 WP_064178387.1 NZ_CP072515:3518093-3518539 [Klebsiella quasipneumoniae]
MKTLNKKETEIQNTLARLRAENPPSLPATEVTATEKKARSEISRQRVSTGLKKVKTIDRQAVIHAIIHDIMLGAISQGEA
LKKLRVEVLGLRQDEYARLVDVSRKTLSDVENDKGNYSAEIINKIFKPFGLETGLVPISKTLISSLFK

Download         Length: 447 bp

>AT197952 NZ_CP096837:c205007-204941 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References