Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 2492037..2493625 | Replicon | chromosome |
| Accession | NZ_CP072515 | ||
| Organism | Klebsiella quasipneumoniae strain 3Z-5L | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | - |
| Locus tag | J6325_RS11990 | Protein ID | WP_224052098.1 |
| Coordinates | 2492303..2493625 (+) | Length | 441 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A2A5MFC9 |
| Locus tag | J6325_RS11985 | Protein ID | WP_004205921.1 |
| Coordinates | 2492037..2492303 (+) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J6325_RS11960 (2487170) | 2487170..2488093 | + | 924 | WP_004205929.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
| J6325_RS11965 (2488074) | 2488074..2489228 | - | 1155 | WP_004205928.1 | FAD-dependent urate hydroxylase HpxO | - |
| J6325_RS11970 (2489574) | 2489574..2490953 | + | 1380 | WP_109938569.1 | nucleobase:cation symporter-2 family protein | - |
| J6325_RS11975 (2490931) | 2490931..2491431 | + | 501 | WP_017900378.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
| J6325_RS11980 (2491428) | 2491428..2491754 | + | 327 | WP_069602708.1 | hydroxyisourate hydrolase | - |
| J6325_RS11985 (2492037) | 2492037..2492303 | + | 267 | WP_004205921.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
| J6325_RS11990 (2492303) | 2492303..2493625 | + | 1323 | WP_224052098.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| J6325_RS11995 (2493642) | 2493642..2494934 | - | 1293 | WP_049093368.1 | glycoside hydrolase family 10 protein | - |
| J6325_RS12000 (2495076) | 2495076..2495282 | - | 207 | WP_004205917.1 | helix-turn-helix transcriptional regulator | - |
| J6325_RS12005 (2495285) | 2495285..2495818 | - | 534 | WP_004205916.1 | hypothetical protein | - |
| J6325_RS12010 (2495847) | 2495847..2496191 | - | 345 | WP_004205915.1 | hypothetical protein | - |
| J6325_RS12015 (2496178) | 2496178..2497293 | - | 1116 | WP_194417688.1 | serine hydrolase domain-containing protein | - |
| J6325_RS12020 (2497562) | 2497562..2498344 | - | 783 | WP_049003659.1 | type I methionyl aminopeptidase | - |
| J6325_RS12025 (2498325) | 2498325..2498543 | - | 219 | WP_002904808.1 | ParD-like family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | iroE / mgtC | 2478063..2718796 | 240733 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49014.30 Da Isoelectric Point: 8.6070
>T197943 WP_224052098.1 NZ_CP072515:2492303-2493625 [Klebsiella quasipneumoniae]
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLAPGEEAHLAALRWQKLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIINTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILGEFADRVP
QAIESARQTLPSDFSAHVWRAITENMLKLHARLQQGLQAG
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLAPGEEAHLAALRWQKLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIINTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILGEFADRVP
QAIESARQTLPSDFSAHVWRAITENMLKLHARLQQGLQAG
Download Length: 1323 bp
>T197943 NZ_CP096834:4606816-4607067 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATATAACTCCCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATATAACTCCCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9940.38 Da Isoelectric Point: 7.1997
>AT197943 WP_004205921.1 NZ_CP072515:2492037-2492303 [Klebsiella quasipneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETAMIP
DNTTDLDW
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETAMIP
DNTTDLDW
Download Length: 267 bp
>AT197943 NZ_CP096834:4607064-4607318 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTTTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTTTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|