Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1110328..1110947 Replicon chromosome
Accession NZ_CP072515
Organism Klebsiella quasipneumoniae strain 3Z-5L

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag J6325_RS05185 Protein ID WP_002892050.1
Coordinates 1110328..1110546 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag J6325_RS05190 Protein ID WP_002892066.1
Coordinates 1110573..1110947 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6325_RS05150 (1106371) 1106371..1106634 + 264 WP_004204754.1 type B 50S ribosomal protein L31 -
J6325_RS05155 (1106634) 1106634..1106774 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
J6325_RS05160 (1106771) 1106771..1107469 - 699 WP_004204753.1 GNAT family protein -
J6325_RS05165 (1107570) 1107570..1109027 + 1458 WP_049117056.1 PLP-dependent aminotransferase family protein -
J6325_RS05170 (1108996) 1108996..1109466 - 471 WP_004204751.1 YlaC family protein -
J6325_RS05175 (1109509) 1109509..1109631 + 123 WP_032426076.1 hypothetical protein -
J6325_RS05180 (1109603) 1109603..1110169 - 567 WP_004204750.1 maltose O-acetyltransferase -
J6325_RS05185 (1110328) 1110328..1110546 - 219 WP_002892050.1 HHA domain-containing protein Toxin
J6325_RS05190 (1110573) 1110573..1110947 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
J6325_RS05195 (1111432) 1111432..1114578 - 3147 WP_004204748.1 multidrug efflux RND transporter permease subunit AcrB -
J6325_RS05200 (1114601) 1114601..1115794 - 1194 WP_004204747.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T197941 WP_002892050.1 NZ_CP072515:c1110546-1110328 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T197941 NZ_CP096834:3816460-3816612 [Escherichia coli]
ATGCTGACAAAATATGCCCTTGTGGCAATCATCGTACTGTGTTGTACAGTACTGGGATTCACGCTGATGGTAGGTGACTC
GTTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT197941 WP_002892066.1 NZ_CP072515:c1110947-1110573 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT197941 NZ_CP096834:c3816420-3816366 [Escherichia coli]
GTTTGGGTTCGAACGTAAGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References