Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 895059..895716 Replicon chromosome
Accession NZ_CP072496
Organism Klebsiella pneumoniae strain KPN247

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag J5253_RS04540 Protein ID WP_002916310.1
Coordinates 895306..895716 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag J5253_RS04535 Protein ID WP_002916312.1
Coordinates 895059..895325 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5253_RS04510 (J5253_04510) 890215..891648 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
J5253_RS04515 (J5253_04515) 891767..892495 - 729 WP_209168157.1 MurR/RpiR family transcriptional regulator -
J5253_RS04520 (J5253_04520) 892545..892856 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
J5253_RS04525 (J5253_04525) 893020..893679 + 660 WP_002916317.1 hemolysin III family protein -
J5253_RS04530 (J5253_04530) 893830..894813 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
J5253_RS04535 (J5253_04535) 895059..895325 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
J5253_RS04540 (J5253_04540) 895306..895716 + 411 WP_002916310.1 protein YgfX Toxin
J5253_RS04545 (J5253_04545) 895723..896244 - 522 WP_002916308.1 flavodoxin FldB -
J5253_RS04550 (J5253_04550) 896345..897241 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
J5253_RS04555 (J5253_04555) 897264..897977 + 714 WP_130955456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
J5253_RS04560 (J5253_04560) 897983..899716 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T197921 WP_002916310.1 NZ_CP072496:895306-895716 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T197921 NZ_CP096831:59110-59262 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT197921 WP_002916312.1 NZ_CP072496:895059-895325 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT197921 NZ_CP096831:c59055-58998 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References