Detailed information of TA system TA197902

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2325597..2327185
• Replicon: chromosome
• Accession: NZ_CP072494
• Organism: Klebsiella pneumoniae strain KPN246

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A6T928
• Locus tag: J7V84_RS11325
• Protein ID: WP_004176197.1
• Coordinates: 2325863..2327185 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: J7V84_RS11320
• Protein ID: WP_002904790.1
• Coordinates: 2325597..2325863 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J7V84_RS11295 (2320748)	2320748..2321671	+	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-
J7V84_RS11300 (2321652)	2321652..2322806	-	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
J7V84_RS11305 (2323152)	2323152..2324531	+	1380	WP_004215088.1	nucleobase:cation symporter-2 family protein	-
J7V84_RS11310 (2324509)	2324509..2325009	+	501	WP_002904787.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
J7V84_RS11315 (2325006)	2325006..2325332	+	327	WP_002904788.1	hydroxyisourate hydrolase	-
J7V84_RS11320 (2325597)	2325597..2325863	+	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
J7V84_RS11325 (2325863)	2325863..2327185	+	1323	WP_004176197.1	type II toxin-antitoxin system HipA family toxin	Toxin
J7V84_RS11330 (2327202)	2327202..2328494	-	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
J7V84_RS11335 (2328636)	2328636..2329640	-	1005	WP_004176196.1	fimbrial protein	-
J7V84_RS11340 (2329628)	2329628..2332129	-	2502	WP_088498182.1	fimbria/pilus outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49111.41 Da
• Isoelectric Point: 7.5357

>T197902 WP_004176197.1 NZ_CP072494:2325863-2327185 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T197902 NZ_CP096821:1744248-1744652 [Pectobacterium sp. 21LCBS03]
ATGCTGAAATATCTACTTGATACCAATATCTGTATTTACACTATCAAGAACAAACCGCAAGAAGTCAGGGATGCTTTCTA
CCGCCATTACGGGCAGTTTGCTATCAGTTCTATCACATTGATGGAACTGATTTATGGTGCGGAGAAATCGGTAAATCCAG
AAAAGAATCTTGCCGTGATTGAAGGGTTTTCTGCGCGTCTCGAAGTTCAAAACTACGGTTTTGACGCTGCCGTGCATACT
GGGCAAATTCGTGCGGAACTGGCAAGACAAGGAACACCCATTGGCCCGTATGATGCCATGCTAGCGGGTCATGCTCGGTC
AGCAGGTTTGATACTGGTAACGAACAATGTGCGTGAGTTTGAGCGTGTGCCAGGATTGCGCGTAGAAAACTGGGTCGGTA
GATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT197902 WP_002904790.1 NZ_CP072494:2325597-2325863 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT197902 NZ_CP096821:1744018-1744248 [Pectobacterium sp. 21LCBS03]
ATGGAAAAAACTACAGTATTTAAAAGCAATCGCAGTCAGGCGGTACGACTCCCTAAAGCTGTTGCACTGCCGGATGATGT
GAAGCAGGTTGATATCGTTGCGATTGGTCGCACACGTATCATTACTCCGGCAGGCGAAAGCTGGGATAGTTGGTTTGAAG
GGGAGAGCGTAACACCTGACTTCGTGATCACCAGAGAGCAACCCGATGAGCAGGTCAGGGAAGATTTTTGA

Structures

Toxin

• AlphaFold DB: A6T928

Antitoxin

• AlphaFold DB: A0A0H3GXD8