Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1063356..1063975 Replicon chromosome
Accession NZ_CP072494
Organism Klebsiella pneumoniae strain KPN246

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag J7V84_RS05150 Protein ID WP_002892050.1
Coordinates 1063356..1063574 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag J7V84_RS05155 Protein ID WP_002892066.1
Coordinates 1063601..1063975 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J7V84_RS05115 (1059403) 1059403..1059666 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
J7V84_RS05120 (1059666) 1059666..1059806 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
J7V84_RS05125 (1059803) 1059803..1060501 - 699 WP_002892021.1 GNAT family protein -
J7V84_RS05130 (1060602) 1060602..1062053 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
J7V84_RS05135 (1062028) 1062028..1062498 - 471 WP_002892026.1 YlaC family protein -
J7V84_RS05140 (1062519) 1062519..1062659 + 141 WP_004147370.1 hypothetical protein -
J7V84_RS05145 (1062631) 1062631..1063197 - 567 WP_002892030.1 maltose O-acetyltransferase -
J7V84_RS05150 (1063356) 1063356..1063574 - 219 WP_002892050.1 HHA domain-containing protein Toxin
J7V84_RS05155 (1063601) 1063601..1063975 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
J7V84_RS05160 (1064461) 1064461..1067607 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
J7V84_RS05165 (1067630) 1067630..1068823 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T197900 WP_002892050.1 NZ_CP072494:c1063574-1063356 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T197900 NZ_CP096820:c6493-6173 [Acinetobacter baumannii]
ATGTTATTCATTGAAACCAGTATTTTTACTAAGCAAATCAAAGAGCTTGTGAGTGATGAAGAGTATCGTCAGCTCCAGCA
AGATCTCTTGGTACAGCCTGATAAGGGCGACTTAATCAAGAATGGTGGTGGAATTCGTAAAGTACGTTGTGCTCAGGGCA
ATAAAGGCAAAAGTGGCGGTATCCGTGTGATCTATTATTGGGTTACAGAAGATGATCAGATCTTTTTCCTGGTGGCTTAT
CCAAAGTCTGTGAAAGATAATCTGACAGACAAAGAAACCTCGATTCTACGTCAATTAGTAAAGGAGCAATTTCATGGATA
A

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT197900 WP_002892066.1 NZ_CP072494:c1063975-1063601 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT197900 NZ_CP096820:c6180-5908 [Acinetobacter baumannii]
ATGGATAACAACTTATTTGATGACCTGGTTGCTTCAATCAAAGAAGCTGGTGCCATCAAGCGTAAGGAGATAAAGGCAAG
TCGAGTCACAGAGCTTGAATTACCGGATATTAAAGAAGTACGTGAGAAAACAGGCTTAACCCAGGCTGAATTTGCTGCAC
GTTTGCATATCAGCGCGAGAACCCTGCAAAACTGGGAACAAGGCCGTCGCTATCCGACTGGTCCTGCAGCGACTTTAATT
CGTATTTTAGATGCTCATCCAACTTTAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References