Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 103394..104304 Replicon plasmid unnamed1
Accession NZ_CP072493
Organism Klebsiella pneumoniae strain KPN236

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag J7V87_RS26310 Protein ID WP_004026354.1
Coordinates 103394..103864 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag J7V87_RS26315 Protein ID WP_004026357.1
Coordinates 103861..104304 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J7V87_RS26290 (J7V87_26285) 98805..99203 - 399 WP_004212796.1 H-NS family nucleoid-associated regulatory protein -
J7V87_RS26295 (J7V87_26290) 99540..100034 - 495 WP_004212794.1 thermonuclease family protein -
J7V87_RS27155 100213..100479 + 267 WP_223175074.1 DUF1173 family protein -
J7V87_RS26300 (J7V87_26295) 100512..101162 + 651 WP_068893702.1 DUF1173 family protein -
J7V87_RS26310 (J7V87_26305) 103394..103864 - 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
J7V87_RS26315 (J7V87_26310) 103861..104304 - 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
J7V87_RS26320 (J7V87_26315) 104405..104908 - 504 Protein_114 DUF4113 domain-containing protein -
J7V87_RS26325 (J7V87_26320) 105006..105227 - 222 WP_004213643.1 DUF2188 domain-containing protein -
J7V87_RS26330 (J7V87_26325) 105408..105527 - 120 Protein_116 Fe3+-citrate ABC transporter substrate-binding protein -
J7V87_RS26335 (J7V87_26330) 105602..107728 - 2127 WP_004213640.1 TonB-dependent Fe(3+) dicitrate receptor FecA -
J7V87_RS26340 (J7V87_26335) 107815..108768 - 954 Protein_118 fec operon regulator FecR -
J7V87_RS26345 (J7V87_26340) 108765..109286 - 522 WP_004213635.1 ferric citrate uptake sigma factor FecI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroB / iroC / iroD / iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 1..231163 231163
- flank IS/Tn - - 102548..103051 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T197897 WP_004026354.1 NZ_CP072493:c103864-103394 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T197897 NZ_CP096818:466442-466831 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT197897 WP_004026357.1 NZ_CP072493:c104304-103861 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT197897 NZ_CP096818:466178-466435 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References