Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4848718..4849234 Replicon chromosome
Accession NZ_CP072492
Organism Klebsiella pneumoniae strain KPN236

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag J7V87_RS23145 Protein ID WP_004178374.1
Coordinates 4848718..4849002 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag J7V87_RS23150 Protein ID WP_002886901.1
Coordinates 4848992..4849234 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J7V87_RS23120 (4844114) 4844114..4844377 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
J7V87_RS23125 (4844507) 4844507..4844680 + 174 WP_041169004.1 hypothetical protein -
J7V87_RS23130 (4844683) 4844683..4845426 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
J7V87_RS23135 (4845783) 4845783..4847921 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
J7V87_RS23140 (4848250) 4848250..4848714 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
J7V87_RS23145 (4848718) 4848718..4849002 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J7V87_RS23150 (4848992) 4848992..4849234 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
J7V87_RS23155 (4849312) 4849312..4851222 - 1911 WP_012737231.1 PRD domain-containing protein -
J7V87_RS23160 (4851245) 4851245..4852399 - 1155 WP_012737230.1 lactonase family protein -
J7V87_RS23165 (4852466) 4852466..4853206 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T197894 WP_004178374.1 NZ_CP072492:c4849002-4848718 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T197894 NZ_CP096814:c5227436-5227053 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT197894 WP_002886901.1 NZ_CP072492:c4849234-4848992 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT197894 NZ_CP096814:c5227678-5227436 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References