Detailed information of TA system TA197879

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazF-pemI/MazF(toxin)
• Location: 200614..201250
• Replicon: chromosome
• Accession: NZ_CP072473
• Organism: Priestia aryabhattai strain LAD

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: D5DWT4
• Locus tag: J5Z55_RS01135
• Protein ID: WP_013055004.1
• Coordinates: 200900..201250 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: pemI
• Uniprot ID: D5DWT3
• Locus tag: J5Z55_RS01130
• Protein ID: WP_013055003.1
• Coordinates: 200614..200895 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5Z55_RS01105 (J5Z55_01105)	195980..196951	+	972	WP_195781429.1	UV DNA damage repair endonuclease UvsE	-
J5Z55_RS01110 (J5Z55_01110)	196960..197562	-	603	WP_098250182.1	rhomboid family intramembrane serine protease	-
J5Z55_RS01115 (J5Z55_01115)	197627..197992	+	366	WP_195783335.1	holo-ACP synthase	-
J5Z55_RS01120 (J5Z55_01120)	198051..199109	+	1059	WP_195781428.1	outer membrane lipoprotein carrier protein LolA	-
J5Z55_RS01125 (J5Z55_01125)	199223..200413	+	1191	WP_195781427.1	alanine racemase	-
J5Z55_RS01130 (J5Z55_01130)	200614..200895	+	282	WP_013055003.1	hypothetical protein	Antitoxin
J5Z55_RS01135 (J5Z55_01135)	200900..201250	+	351	WP_013055004.1	type II toxin-antitoxin system endoribonuclease NdoA	Toxin
J5Z55_RS01140 (J5Z55_01140)	201410..202246	+	837	WP_013055005.1	RsbT co-antagonist protein RsbRA	-
J5Z55_RS01145 (J5Z55_01145)	202249..202605	+	357	WP_013055006.1	STAS domain-containing protein	-
J5Z55_RS01150 (J5Z55_01150)	202609..203010	+	402	WP_013055007.1	anti-sigma regulatory factor	-
J5Z55_RS01155 (J5Z55_01155)	203024..204034	+	1011	WP_195781426.1	PP2C family protein-serine/threonine phosphatase	-
J5Z55_RS01160 (J5Z55_01160)	204094..204426	+	333	WP_013055009.1	anti-sigma factor antagonist	-
J5Z55_RS01165 (J5Z55_01165)	204423..204908	+	486	WP_025753516.1	anti-sigma B factor RsbW	-
J5Z55_RS01170 (J5Z55_01170)	204874..205668	+	795	WP_013055011.1	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12991.96 Da
• Isoelectric Point: 4.8781

>T197879 WP_013055004.1 NZ_CP072473:200900-201250 [Priestia aryabhattai]
MVVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDRVDEALQISVGLIDF

Nucleotide

• Length: 351 bp

>T197879 NZ_CP096813:c1524149-1523868 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10691.22 Da
• Isoelectric Point: 8.5339

>AT197879 WP_013055003.1 NZ_CP072473:200614-200895 [Priestia aryabhattai]
VSEASATTEILVRLPKNLVSELDLMVKQENGNRSDFIHQATKLYLRERKKRHIRESMRRGYMEMAKINLNIASEAFLAEY
EADHTVDRLVSGG

Nucleotide

• Length: 282 bp

>AT197879 NZ_CP096813:c1524373-1524146 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0B6AMB9