Detailed information of TA system TA197875

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4860102..4860615
• Replicon: chromosome
• Accession: NZ_CP072468
• Organism: Klebsiella quasipneumoniae strain B6885

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: J6315_RS23530
• Protein ID: WP_109546715.1
• Coordinates: 4860102..4860383 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: J6315_RS23535
• Protein ID: WP_023319595.1
• Coordinates: 4860373..4860615 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6315_RS23520 (4857100)	4857100..4859238	+	2139	WP_004206513.1	anaerobic ribonucleoside-triphosphate reductase	-
J6315_RS23525 (4859634)	4859634..4860098	+	465	WP_109546714.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
J6315_RS23530 (4860102)	4860102..4860383	-	282	WP_109546715.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J6315_RS23535 (4860373)	4860373..4860615	-	243	WP_023319595.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
J6315_RS23540 (4860693)	4860693..4862603	-	1911	WP_109546716.1	PRD domain-containing protein	-
J6315_RS23545 (4862626)	4862626..4863780	-	1155	WP_109546717.1	lactonase family protein	-
J6315_RS23550 (4863847)	4863847..4864587	-	741	WP_004206507.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (18-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-64)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10982.81 Da
• Isoelectric Point: 10.4134

>T197875 WP_109546715.1 NZ_CP072468:c4860383-4860102 [Klebsiella quasipneumoniae]
MTYELAFDPRAWREWQLGETVKKQFKNKLQQIVQNPRIESARLNDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGKR
EKAAVYHQANKRL

Nucleotide

• Length: 282 bp

>T197875 NZ_CP096812:447097-447486 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAGTAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9089.55 Da
• Isoelectric Point: 4.8146

>AT197875 WP_023319595.1 NZ_CP072468:c4860615-4860373 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPQPEVKVSLDDL

Nucleotide

• Length: 243 bp

>AT197875 NZ_CP096812:446833-447090 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCATTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA