Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1254637..1255286 Replicon chromosome
Accession NZ_CP072467
Organism Spiractinospora alimapuensis strain VN6-2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J4H86_RS05790 Protein ID WP_236542471.1
Coordinates 1254637..1255056 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J4H86_RS05795 Protein ID WP_236542472.1
Coordinates 1255053..1255286 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4H86_RS05780 (J4H86_05750) 1252150..1252602 - 453 WP_236542469.1 GreA/GreB family elongation factor -
J4H86_RS05785 (J4H86_05755) 1253036..1254619 + 1584 WP_236542470.1 helix-turn-helix domain-containing protein -
J4H86_RS05790 (J4H86_05760) 1254637..1255056 - 420 WP_236542471.1 type II toxin-antitoxin system VapC family toxin Toxin
J4H86_RS05795 (J4H86_05765) 1255053..1255286 - 234 WP_236542472.1 toxin-antitoxin system Antitoxin
J4H86_RS05800 (J4H86_05770) 1255342..1256016 - 675 WP_236542473.1 DUF1028 domain-containing protein -
J4H86_RS05805 (J4H86_05775) 1256109..1256330 + 222 WP_236542474.1 DUF2945 domain-containing protein -
J4H86_RS05810 (J4H86_05780) 1256339..1256887 + 549 WP_236542475.1 DUF488 domain-containing protein -
J4H86_RS05815 (J4H86_05785) 1256963..1257484 + 522 WP_236542476.1 helix-turn-helix domain-containing protein -
J4H86_RS05820 (J4H86_05790) 1257481..1258341 + 861 WP_236542477.1 M23 family metallopeptidase -
J4H86_RS05825 (J4H86_05795) 1258607..1259977 + 1371 WP_236542478.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15229.35 Da        Isoelectric Point: 4.6381

>T197862 WP_236542471.1 NZ_CP072467:c1255056-1254637 [Spiractinospora alimapuensis]
MIVLDTNVISEIFRPNPDERVVTWLGSLTGEVAVTAVTLAELRAGVGRLPEGKRRSALQMRIEAALQPYRETRAILVFDD
DAAGHYAEIVVARERAGIPISMADAQIAAMCRSNSATCATRNTKDFTETGIELINPWDE

Download         Length: 420 bp

>T197862 NZ_CP096810:3615058-3615426 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GCCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8235.55 Da        Isoelectric Point: 6.4613

>AT197862 WP_236542472.1 NZ_CP072467:c1255286-1255053 [Spiractinospora alimapuensis]
MASIVVRGLDESVKKQIAIQAKEHGHSMEAEVREILTRAAGRPNIGIALMRAVMDVGGVDDLPVPVRTDAARVVDFG

Download         Length: 234 bp

>AT197862 NZ_CP096810:3614840-3615061 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References