Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 452102..452660 Replicon chromosome
Accession NZ_CP072467
Organism Spiractinospora alimapuensis strain VN6-2

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag J4H86_RS01960 Protein ID WP_236543870.1
Coordinates 452102..452344 (-) Length 81 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J4H86_RS01965 Protein ID WP_236541477.1
Coordinates 452382..452660 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4H86_RS01940 (J4H86_01930) 447832..448722 - 891 WP_236541472.1 alpha/beta hydrolase -
J4H86_RS01945 (J4H86_01935) 448740..449432 - 693 WP_236543869.1 maleylpyruvate isomerase N-terminal domain-containing protein -
J4H86_RS01950 (J4H86_01940) 449432..450394 - 963 WP_236541474.1 prolyl aminopeptidase -
J4H86_RS01955 (J4H86_01945) 450557..452080 + 1524 WP_236541475.1 multicopper oxidase domain-containing protein -
J4H86_RS01960 (J4H86_01950) 452102..452344 - 243 WP_236543870.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J4H86_RS01965 (J4H86_01955) 452382..452660 - 279 WP_236541477.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J4H86_RS01970 (J4H86_01960) 452797..454419 + 1623 WP_236541478.1 histidine kinase -
J4H86_RS01975 (J4H86_01965) 454447..455130 + 684 WP_236541479.1 response regulator transcription factor -
J4H86_RS01980 (J4H86_01970) 455175..456386 + 1212 WP_236541481.1 sigma factor -
J4H86_RS01985 (J4H86_01975) 456373..456732 - 360 WP_236541483.1 YciI family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(25-77)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 81 a.a.        Molecular weight: 9018.23 Da        Isoelectric Point: 9.8568

>T197860 WP_236543870.1 NZ_CP072467:c452344-452102 [Spiractinospora alimapuensis]
VARALSNRLPQKVAHAVCEFITSVLLDNPRRVGKELLLPPYDGTYSARRGTYRVLYGIDDESRTVTVTAVEHRGDAYRSR

Download         Length: 243 bp

>T197860 NZ_CP096810:c2850822-2849905 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGGGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10280.52 Da        Isoelectric Point: 4.2149

>AT197860 WP_236541477.1 NZ_CP072467:c452660-452382 [Spiractinospora alimapuensis]
METLPLTEARNRLSELVDDVQRTHQRVTITRHGEVAAVIMSADDLDALEETLEVLSSPELMGQLAESKIAREQGDVLDVD
QLRSLMAEHRGE

Download         Length: 279 bp

>AT197860 NZ_CP096810:c2851586-2850828 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCGTATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References