Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2800418..2802006 Replicon chromosome
Accession NZ_CP072463
Organism Klebsiella pneumoniae strain KP1517

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag HRG83_RS13940 Protein ID WP_004199851.1
Coordinates 2800418..2801740 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag HRG83_RS13945 Protein ID WP_002904790.1
Coordinates 2801740..2802006 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRG83_RS13925 (HRG83_13925) 2795483..2797984 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
HRG83_RS13930 (HRG83_13930) 2797972..2798976 + 1005 WP_004199852.1 fimbrial protein -
HRG83_RS13935 (HRG83_13935) 2799109..2800401 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
HRG83_RS13940 (HRG83_13940) 2800418..2801740 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
HRG83_RS13945 (HRG83_13945) 2801740..2802006 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
HRG83_RS13950 (HRG83_13950) 2802272..2802598 - 327 WP_002904788.1 hydroxyisourate hydrolase -
HRG83_RS13955 (HRG83_13955) 2802595..2803095 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
HRG83_RS13960 (HRG83_13960) 2803073..2804452 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
HRG83_RS13965 (HRG83_13965) 2804798..2805952 + 1155 Protein_2744 FAD-dependent urate hydroxylase HpxO -
HRG83_RS13970 (HRG83_13970) 2805933..2806856 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T197845 WP_004199851.1 NZ_CP072463:c2801740-2800418 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T197845 NZ_CP096776:c12179-11796 [Proteus mirabilis]
ATGATATGGGTTAGCGCACAGGAAGTTATCGCTTTCCATGATCGTATATTACAACGTTTCCCAGGTGTGGCCGGTATGCC
CGATCCTGGCAGAGCGGAAGCTCTTATTTACCGGGTGCAAAACCGTAAACATTATGAAGGCATTACAGATGTGTTTGAAC
TGGCAGCAACTTATTGGGTCGCTATCGCTCGAGGGCACATATTTAATGACGGTAATAAACGTACCGCATTTTTTGTGACC
ATGACATTTCTCTATCGTAATGGCATCAGGATCCGCGATACTGGCAATATGCTGGAAAACTTAACAGTAGAAGCAGCTAC
AGGTGAGAAAACCGTCGACCAGTTAGCAAAACATCTACAAAACTTGGTAGAGAAAACTAACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT197845 WP_002904790.1 NZ_CP072463:c2802006-2801740 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT197845 NZ_CP096776:c12397-12176 [Proteus mirabilis]
ATGCGTACATATACCTCGACACAAGCCCGAGCTAATATTTCAGAAGTATTAGATATTGCGACCCACGGTGAACCTGTTGA
AATCACCCGCAGAGACGGTTGTTCAGCGGTTGTTATCAGTAAAACTGAATTTGAGTCATACCAGAATGCTAAGCTAGATG
CAGAGTTTGATATGATGATGCAACGTCATGGACATACCGTAGAGGCACTGACAAATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References