Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 875178..875832 Replicon chromosome
Accession NZ_CP072463
Organism Klebsiella pneumoniae strain KP1517

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag HRG83_RS04415 Protein ID WP_004144731.1
Coordinates 875425..875832 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HRG83_RS04410 Protein ID WP_002916312.1
Coordinates 875178..875444 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRG83_RS04385 (HRG83_04385) 870334..871767 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
HRG83_RS04390 (HRG83_04390) 871886..872614 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HRG83_RS04395 (HRG83_04395) 872664..872975 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
HRG83_RS04400 (HRG83_04400) 873139..873798 + 660 WP_002916317.1 hemolysin III family protein -
HRG83_RS04405 (HRG83_04405) 873949..874932 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HRG83_RS04410 (HRG83_04410) 875178..875444 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HRG83_RS04415 (HRG83_04415) 875425..875832 + 408 WP_004144731.1 protein YgfX Toxin
HRG83_RS04420 (HRG83_04420) 875839..876360 - 522 WP_002916308.1 flavodoxin FldB -
HRG83_RS04425 (HRG83_04425) 876461..877357 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HRG83_RS04430 (HRG83_04430) 877380..878093 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HRG83_RS04435 (HRG83_04435) 878099..879832 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T197836 WP_004144731.1 NZ_CP072463:875425-875832 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T197836 NZ_CP096766:447092-447481 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT197836 WP_002916312.1 NZ_CP072463:875178-875444 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT197836 NZ_CP096766:446828-447085 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References