Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4871634..4872431 Replicon chromosome
Accession NZ_CP072460
Organism Klebsiella pneumoniae strain K-1L

Toxin (Protein)


Gene name yeeV Uniprot ID A0A346GMF9
Locus tag J7V83_RS23925 Protein ID WP_072644276.1
Coordinates 4872054..4872431 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A346GRC6
Locus tag J7V83_RS23920 Protein ID WP_072648994.1
Coordinates 4871634..4872008 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J7V83_RS23895 (4869062) 4869062..4869295 + 234 WP_064986988.1 DUF905 family protein -
J7V83_RS23900 (4869385) 4869385..4870203 + 819 WP_072644256.1 DUF932 domain-containing protein -
J7V83_RS23905 (4870294) 4870294..4870779 + 486 WP_072648993.1 antirestriction protein -
J7V83_RS23910 (4870795) 4870795..4871271 + 477 WP_001297237.1 RadC family protein -
J7V83_RS23915 (4871334) 4871334..4871555 + 222 WP_000692353.1 DUF987 domain-containing protein -
J7V83_RS23920 (4871634) 4871634..4872008 + 375 WP_072648994.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
J7V83_RS23925 (4872054) 4872054..4872431 + 378 WP_072644276.1 TA system toxin CbtA family protein Toxin
J7V83_RS23930 (4872428) 4872428..4872595 + 168 Protein_4671 DUF5983 family protein -
J7V83_RS23935 (4872653) 4872653..4872850 + 198 WP_094770706.1 DUF957 domain-containing protein -
J7V83_RS23940 (4872947) 4872947..4873792 + 846 WP_001280435.1 DUF4942 domain-containing protein -
J7V83_RS23950 (4874091) 4874091..4874597 + 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
J7V83_RS23955 (4874697) 4874697..4876538 - 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14231.23 Da        Isoelectric Point: 7.7761

>T197829 WP_072644276.1 NZ_CP072460:4872054-4872431 [Klebsiella pneumoniae]
MKTLPDTYVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNDITQGKHPEVKR

Download         Length: 378 bp

>T197829 NZ_CP096758:c7841-7554 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGATATACTAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13869.65 Da        Isoelectric Point: 6.2043

>AT197829 WP_072648994.1 NZ_CP072460:4871634-4872008 [Klebsiella pneumoniae]
VSDKLHETNYPDDHNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT197829 NZ_CP096758:c7567-7253 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A346GMF9

Antitoxin

Source ID Structure
AlphaFold DB A0A346GRC6

References