Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4080407..4081032 Replicon chromosome
Accession NZ_CP072460
Organism Klebsiella pneumoniae strain K-1L

Toxin (Protein)


Gene name vapC Uniprot ID A0A483GDF6
Locus tag J7V83_RS20095 Protein ID WP_004187928.1
Coordinates 4080407..4080790 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag J7V83_RS20100 Protein ID WP_004150355.1
Coordinates 4080790..4081032 (-) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J7V83_RS20080 (4077773) 4077773..4078675 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
J7V83_RS20085 (4078672) 4078672..4079307 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
J7V83_RS20090 (4079304) 4079304..4080233 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
J7V83_RS20095 (4080407) 4080407..4080790 - 384 WP_004187928.1 type II toxin-antitoxin system VapC family toxin Toxin
J7V83_RS20100 (4080790) 4080790..4081032 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
J7V83_RS20105 (4081226) 4081226..4082143 + 918 WP_004187929.1 alpha/beta hydrolase -
J7V83_RS20110 (4082157) 4082157..4083098 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
J7V83_RS20115 (4083143) 4083143..4083580 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
J7V83_RS20120 (4083577) 4083577..4084437 - 861 WP_004146232.1 virulence factor BrkB family protein -
J7V83_RS20125 (4084431) 4084431..4085030 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-110)

Antitoxin

(16-47)


Sequences


Toxin        


Download         Length: 128 a.a.        Molecular weight: 14407.64 Da        Isoelectric Point: 7.3178

>T197826 WP_004187928.1 NZ_CP072460:c4080790-4080407 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFTGIPGVVTPYEIHPE

Download         Length: 384 bp

>T197826 NZ_CP096756:c11186-10827 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAGAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT197826 WP_004150355.1 NZ_CP072460:c4081032-4080790 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT197826 NZ_CP096756:c10827-10528 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A483GDF6


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References