Detailed information of TA system TA197825

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3762524..3764205
• Replicon: chromosome
• Accession: NZ_CP072460
• Organism: Klebsiella pneumoniae strain K-1L

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: W8V1Q6
• Locus tag: J7V83_RS18620
• Protein ID: WP_002885155.1
• Coordinates: 3762524..3763441 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A2L1C4M5
• Locus tag: J7V83_RS18625
• Protein ID: WP_004192584.1
• Coordinates: 3763447..3764205 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J7V83_RS18600 (3757830)	3757830..3759350	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
J7V83_RS18605 (3759347)	3759347..3760345	+	999	WP_002885172.1	ribose ABC transporter permease	-
J7V83_RS18610 (3760376)	3760376..3761317	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
J7V83_RS18615 (3761392)	3761392..3762399	+	1008	WP_004177805.1	carbohydrate kinase family protein	-
J7V83_RS18620 (3762524)	3762524..3763441	-	918	WP_002885155.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
J7V83_RS18625 (3763447)	3763447..3764205	-	759	WP_004192584.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
J7V83_RS18630 (3764291)	3764291..3765019	-	729	WP_002885152.1	response regulator transcription factor	-
J7V83_RS18635 (3765292)	3765292..3767439	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
J7V83_RS18640 (3767669)	3767669..3768355	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34687.15 Da
• Isoelectric Point: 5.4707

>T197825 WP_002885155.1 NZ_CP072460:c3763441-3762524 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T197825 NZ_CP096755:3346239-3346418 [Acinetobacter baumannii]
ATGAGCTTCAACGAGTTTAAACGATGGCTAATTGCACAGGGAGTTATCTTTGTGCGTAAAGGTAAGGGATCACATATGAT
TATTGAATTTAACGGTAAGAAGACTGTTTTCCCTAACCACGGGAAAAAAGAAATTCCTGAGGGCACTCGTTTAAAAATCA
AAAAGGATTTGGGGCTTTAA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28582.94 Da
• Isoelectric Point: 10.0870

>AT197825 WP_004192584.1 NZ_CP072460:c3764205-3763447 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDAFACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT197825 NZ_CP096755:3346508-3346921 [Acinetobacter baumannii]
ATGAAATATTACGTGAGTATAGTACAGGAGGAAGGAGCTTATATAGTTAGCTCTCGGGACCTTCCTCTGTTAAATAGCGT
AGGCTATACATTAGAAGAAGCTTTATCTGAAGCTTTGGATGGTATAGAAACTACTTTCGAAATTTATATGGATGAGCGTA
AGGCTATTCCTTTACCATCAAAAGGAAAGAAAGATGAATATGAAATTCATCTTCCAGTTCGAGTTGCTGCTAAGGTACGT
TTATATAATGAGATGATCTCTCAAGACGTTACTAAGGCTGAATTAGCTCGTCGCTTGGGGTGGTTACAGAAGCAAGCCGA
CCGTTTGCTTTCATTAAAGCATTCAACAAAATTAGAGTCTATCGAAAGTGCATTTCATGCATTAGGTAAAGATCTCGATA
TTGTTGTTGCATAA

Structures

Toxin

• AlphaFold DB: A0A0H3GH11

Antitoxin

• AlphaFold DB: A0A2L1C4M5