Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3597307..3597823 Replicon chromosome
Accession NZ_CP072460
Organism Klebsiella pneumoniae strain K-1L

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag J7V83_RS17785 Protein ID WP_009309309.1
Coordinates 3597307..3597591 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag J7V83_RS17790 Protein ID WP_002886901.1
Coordinates 3597581..3597823 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J7V83_RS17760 (3592724) 3592724..3593032 - 309 WP_004192389.1 PTS sugar transporter subunit IIB -
J7V83_RS17765 (3593117) 3593117..3593290 + 174 WP_002886906.1 hypothetical protein -
J7V83_RS17770 (3593293) 3593293..3594036 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
J7V83_RS17775 (3594393) 3594393..3596531 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
J7V83_RS17780 (3596839) 3596839..3597303 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
J7V83_RS17785 (3597307) 3597307..3597591 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J7V83_RS17790 (3597581) 3597581..3597823 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
J7V83_RS17795 (3597901) 3597901..3599811 - 1911 WP_009486549.1 PRD domain-containing protein -
J7V83_RS17800 (3599834) 3599834..3600988 - 1155 WP_002886900.1 lactonase family protein -
J7V83_RS17805 (3601055) 3601055..3601795 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T197824 WP_009309309.1 NZ_CP072460:c3597591-3597307 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T197824 NZ_CP096755:452185-452574 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT197824 WP_002886901.1 NZ_CP072460:c3597823-3597581 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT197824 NZ_CP096755:451921-452178 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References