Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3503480..3504315 | Replicon | chromosome |
| Accession | NZ_CP072460 | ||
| Organism | Klebsiella pneumoniae strain K-1L | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A5E2RWI0 |
| Locus tag | J7V83_RS17385 | Protein ID | WP_001559913.1 |
| Coordinates | 3503480..3503857 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A5E3EVB5 |
| Locus tag | J7V83_RS17390 | Protein ID | WP_032408847.1 |
| Coordinates | 3503947..3504315 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J7V83_RS17345 (3498744) | 3498744..3499010 | + | 267 | WP_004178415.1 | hypothetical protein | - |
| J7V83_RS17350 (3499010) | 3499010..3499682 | + | 673 | Protein_3401 | DUF4400 domain-containing protein | - |
| J7V83_RS17355 (3499693) | 3499693..3500577 | + | 885 | WP_004192285.1 | RES domain-containing protein | - |
| J7V83_RS17360 (3500776) | 3500776..3500964 | - | 189 | Protein_3403 | transposase | - |
| J7V83_RS17365 (3500981) | 3500981..3502092 | - | 1112 | Protein_3404 | IS3 family transposase | - |
| J7V83_RS17370 (3502544) | 3502544..3502693 | - | 150 | Protein_3405 | restriction endonuclease subunit M | - |
| J7V83_RS17375 (3502778) | 3502778..3502975 | - | 198 | WP_032408848.1 | DUF957 domain-containing protein | - |
| J7V83_RS17380 (3502995) | 3502995..3503483 | - | 489 | WP_001559914.1 | DUF5983 family protein | - |
| J7V83_RS17385 (3503480) | 3503480..3503857 | - | 378 | WP_001559913.1 | TA system toxin CbtA family protein | Toxin |
| J7V83_RS17390 (3503947) | 3503947..3504315 | - | 369 | WP_032408847.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| J7V83_RS17395 (3504492) | 3504492..3504713 | - | 222 | WP_000692300.1 | DUF987 domain-containing protein | - |
| J7V83_RS17400 (3504782) | 3504782..3505258 | - | 477 | WP_032408846.1 | RadC family protein | - |
| J7V83_RS17405 (3505273) | 3505273..3505758 | - | 486 | WP_088607457.1 | antirestriction protein | - |
| J7V83_RS17410 (3505850) | 3505850..3506668 | - | 819 | WP_001559911.1 | DUF932 domain-containing protein | - |
| J7V83_RS17415 (3506768) | 3506768..3507001 | - | 234 | WP_001119729.1 | DUF905 family protein | - |
| J7V83_RS17420 (3507080) | 3507080..3507535 | - | 456 | WP_000581504.1 | IrmA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3492855..3522271 | 29416 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14148.10 Da Isoelectric Point: 7.8276
>T197823 WP_001559913.1 NZ_CP072460:c3503857-3503480 [Klebsiella pneumoniae]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
Download Length: 378 bp
>T197823 NZ_CP096754:c11212-10853 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAGAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAGAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13682.62 Da Isoelectric Point: 7.8398
>AT197823 WP_032408847.1 NZ_CP072460:c3504315-3503947 [Klebsiella pneumoniae]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVMLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVMLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
Download Length: 369 bp
>AT197823 NZ_CP096754:c10853-10554 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5E2RWI0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5E3EVB5 |