Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 713191..713988 Replicon chromosome
Accession NZ_CP072456
Organism Klebsiella pneumoniae strain b1-2L

Toxin (Protein)


Gene name yeeV Uniprot ID A0A346GMF9
Locus tag J7V71_RS03470 Protein ID WP_072644276.1
Coordinates 713611..713988 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A346GRC6
Locus tag J7V71_RS03465 Protein ID WP_072648994.1
Coordinates 713191..713565 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J7V71_RS03440 (710619) 710619..710852 + 234 WP_064986988.1 DUF905 family protein -
J7V71_RS03445 (710942) 710942..711760 + 819 WP_072644256.1 DUF932 domain-containing protein -
J7V71_RS03450 (711851) 711851..712336 + 486 WP_072648993.1 antirestriction protein -
J7V71_RS03455 (712352) 712352..712828 + 477 WP_001297237.1 RadC family protein -
J7V71_RS03460 (712891) 712891..713112 + 222 WP_000692353.1 DUF987 domain-containing protein -
J7V71_RS03465 (713191) 713191..713565 + 375 WP_072648994.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
J7V71_RS03470 (713611) 713611..713988 + 378 WP_072644276.1 TA system toxin CbtA family protein Toxin
J7V71_RS03475 (713985) 713985..714134 + 150 Protein_682 DUF5983 family protein -
J7V71_RS03480 (714210) 714210..714407 + 198 WP_094770706.1 DUF957 domain-containing protein -
J7V71_RS03485 (714504) 714504..715349 + 846 WP_001280435.1 DUF4942 domain-containing protein -
J7V71_RS03495 (715648) 715648..716154 + 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
J7V71_RS03500 (716254) 716254..718095 - 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14231.23 Da        Isoelectric Point: 7.7761

>T197791 WP_072644276.1 NZ_CP072456:713611-713988 [Klebsiella pneumoniae]
MKTLPDTYVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNDITQGKHPEVKR

Download         Length: 378 bp

>T197791 NZ_CP096715:c19487-19200 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGATATACTAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13869.65 Da        Isoelectric Point: 6.2043

>AT197791 WP_072648994.1 NZ_CP072456:713191-713565 [Klebsiella pneumoniae]
VSDKLHETNYPDDHNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT197791 NZ_CP096715:c19213-18899 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A346GMF9

Antitoxin

Source ID Structure
AlphaFold DB A0A346GRC6

References