Detailed information of TA system TA197787

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 4109548..4110197
• Replicon: chromosome
• Accession: NZ_CP072455
• Organism: Xenorhabdus budapestensis strain C-7-2

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: HGO23_RS18120
• Protein ID: WP_099134229.1
• Coordinates: 4109548..4109973 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A2D0J4V3
• Locus tag: HGO23_RS18125
• Protein ID: WP_047683259.1
• Coordinates: 4109970..4110197 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGO23_RS19850	4104782..4106215	+	1434	WP_244967841.1	RHS repeat-associated core domain-containing protein	-
HGO23_RS18100 (HGO23_18100)	4106541..4106861	-	321	WP_209027428.1	SymE family type I addiction module toxin	-
HGO23_RS18105 (HGO23_18105)	4107003..4107281	-	279	WP_244967842.1	SymE family type I addiction module toxin	-
HGO23_RS18110 (HGO23_18110)	4107457..4108272	+	816	WP_209027429.1	hypothetical protein	-
HGO23_RS18115 (HGO23_18115)	4108574..4109464	+	891	WP_099134230.1	EamA family transporter RarD	-
HGO23_RS18120 (HGO23_18120)	4109548..4109973	-	426	WP_099134229.1	type II toxin-antitoxin system VapC family toxin	Toxin
HGO23_RS18125 (HGO23_18125)	4109970..4110197	-	228	WP_047683259.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
HGO23_RS18130 (HGO23_18130)	4110405..4111355	-	951	WP_099134228.1	magnesium/cobalt transporter CorA	-
HGO23_RS18135 (HGO23_18135)	4111576..4113741	-	2166	WP_209027430.1	DNA helicase II	-
HGO23_RS18140 (HGO23_18140)	4113807..4114523	-	717	WP_209027431.1	5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase YigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-128)

Antitoxin

• SpoVT-AbrB domain (7-54)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 15474.95 Da
• Isoelectric Point: 7.2132

>T197787 WP_099134229.1 NZ_CP072455:c4109973-4109548 [Xenorhabdus budapestensis]
MKKLYMLDTNICSFIMREPPIAVINQLQKCVMNNYPIVVSAITYSEMRFGAIGEKASPKHGVLVDEFCKRLDGILSWDKS
AVDATTKVKVALTSAGTSIGHNDTAIAGHALSVGAILVTNNTREFSRVIGLPLEDWTEIYQ

Nucleotide

• Length: 426 bp

>T197787 NZ_CP096714:449811-450200 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8714.86 Da
• Isoelectric Point: 4.5216

>AT197787 WP_047683259.1 NZ_CP072455:c4110197-4109970 [Xenorhabdus budapestensis]
MRTVAVFKNGNNRAIRLPKDLDFEGVNELEIIREGETIILRPVKPSWHSFLSEDKADEDFLSERPDIIEEGRFTL

Nucleotide

• Length: 228 bp

>AT197787 NZ_CP096714:449547-449804 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A2D0J4V3