Detailed information of TA system TA197786

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3644300..3644918
• Replicon: chromosome
• Accession: NZ_CP072455
• Organism: Xenorhabdus budapestensis strain C-7-2

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: N1NUC1
• Locus tag: HGO23_RS16045
• Protein ID: WP_010845060.1
• Coordinates: 3644715..3644918 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: HGO23_RS16040
• Protein ID: WP_099135813.1
• Coordinates: 3644300..3644668 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGO23_RS16035 (HGO23_16035)	3640204..3643338	+	3135	WP_209027243.1	efflux RND transporter permease subunit	-
HGO23_RS16040 (HGO23_16040)	3644300..3644668	+	369	WP_099135813.1	Hha toxicity modulator TomB	Antitoxin
HGO23_RS16045 (HGO23_16045)	3644715..3644918	+	204	WP_010845060.1	HHA domain-containing protein	Toxin
HGO23_RS16055 (HGO23_16055)	3646025..3646894	+	870	WP_099135814.1	acyl-CoA thioesterase II	-
HGO23_RS16060 (HGO23_16060)	3647001..3648281	-	1281	WP_099135815.1	ammonium transporter AmtB	-
HGO23_RS16065 (HGO23_16065)	3648297..3648635	-	339	WP_038262238.1	P-II family nitrogen regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-114)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8077.34 Da
• Isoelectric Point: 6.9770

>T197786 WP_010845060.1 NZ_CP072455:3644715-3644918 [Xenorhabdus budapestensis]
MTKTDYLMRLRKCTSIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Nucleotide

• Length: 204 bp

>T197786 NZ_CP096713:c31981-31625 [Acinetobacter baumannii]
ATGTGGACAGTCATTACAACGGATCTGTTTAATGAATGGCTTGAACAGCAAGATGAAGCAACACAAGAGAAAGTCTTAGC
TGCATTGGTTGTTCTACAACAGCAAGGGCCTAGTTTAGGTCGTCCTTTAGTAGATACCGTCTACGATTCTAAATTTACCA
ATATGAAGGAACTACGTGTTCAGCATCGTGGTAAACCGTTAAGGGCATTTTTTGCATTCGATCCCCTAAGACAAGCGATT
GTGCTGTGTATTGGTGATAAGAGTAATAAAAAGCGTTTTTATACAGAGATGCTAGCAATTGCAGATGAGCAATACGCACT
TCATCTCTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 14564.47 Da
• Isoelectric Point: 5.1978

>AT197786 WP_099135813.1 NZ_CP072455:3644300-3644668 [Xenorhabdus budapestensis]
MDEYSPRRHDIAELKYLCENLIPEAFSVLNRTDNHWINDLTSEKSLRLNEFIEHITVFVWSFKIKYTDNYNLSTLIDKYL
DETYNLFGSDKISFVELTKWQRTNERLTSILLHDLNASLSKI

Nucleotide

• Length: 369 bp

>AT197786 NZ_CP096713:c31632-31330 [Acinetobacter baumannii]
ATGGCTAAGAGCTTACAAGAATTATTGGCTAGTCGCTCTCCAGAGAGTCAAGCTCGTATTCAAAAAATGGCTGATGAATT
ACTTTTAGAAAGTCAGCTTCACCTTATCCGAGAAGAGTTAGAAATTTCCCAGAAAGAACTAGCTGCAACCCTTGGAATTA
AACAGCCGTCATTATCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTTGAAGCAATG
GGTGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGGTTCAATGTCTAA

Structures

Toxin

• AlphaFold DB: N1NUC1