Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1218290..1218817 Replicon chromosome
Accession NZ_CP072455
Organism Xenorhabdus budapestensis strain C-7-2

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag HGO23_RS05545 Protein ID WP_209028225.1
Coordinates 1218509..1218817 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag HGO23_RS05540 Protein ID WP_209028224.1
Coordinates 1218290..1218508 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGO23_RS05510 (HGO23_05510) 1213349..1213975 + 627 WP_209028221.1 TetR/AcrR family transcriptional regulator -
HGO23_RS05515 (HGO23_05515) 1214492..1215045 - 554 Protein_1093 conjugative transfer ATPase -
HGO23_RS05525 (HGO23_05525) 1215839..1216030 + 192 WP_209028222.1 hypothetical protein -
HGO23_RS05530 (HGO23_05530) 1216088..1217488 - 1401 Protein_1096 ISKra4 family transposase -
HGO23_RS05535 (HGO23_05535) 1217513..1218094 - 582 WP_209028223.1 recombinase family protein -
HGO23_RS05540 (HGO23_05540) 1218290..1218508 + 219 WP_209028224.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
HGO23_RS05545 (HGO23_05545) 1218509..1218817 + 309 WP_209028225.1 type II toxin-antitoxin system toxin CcdB Toxin
HGO23_RS05550 (HGO23_05550) 1219076..1220578 - 1503 WP_209028226.1 Tn3 family transposase -
HGO23_RS05555 (HGO23_05555) 1220624..1220984 + 361 Protein_1101 recombinase family protein -
HGO23_RS05560 (HGO23_05560) 1221133..1221750 - 618 WP_209028227.1 DJ-1/PfpI family protein -
HGO23_RS05565 (HGO23_05565) 1221976..1223721 + 1746 WP_209028228.1 beta-ketoacyl synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11769.47 Da        Isoelectric Point: 5.5740

>T197782 WP_209028225.1 NZ_CP072455:1218509-1218817 [Xenorhabdus budapestensis]
MQFFVYQYKRSGSKYSMFVDVQSDIIETLGRRMVIPLVEAHHFSNKVSNHLFPIVQIKDGNYRLLTTELSSVPESVIGEE
ITDLSQWSSDIKDAINLLFWGI

Download         Length: 309 bp

>T197782 NZ_CP096710:449610-449999 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8306.35 Da        Isoelectric Point: 7.0108

>AT197782 WP_209028224.1 NZ_CP072455:1218290-1218508 [Xenorhabdus budapestensis]
MKHRVNVTVDKANYLTLSAAGVNISGFINEVMTKEVQRIKAENWKEENRKGMEEVAQFIAQYGSFADENRNW

Download         Length: 219 bp

>AT197782 NZ_CP096710:449346-449603 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References