Detailed information of TA system TA197778

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 4553678..4554323
• Replicon: chromosome
• Accession: NZ_CP072453
• Organism: Providencia sp. R33

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: B6XA97
• Locus tag: J6836_RS21100
• Protein ID: WP_004905417.1
• Coordinates: 4553678..4553881 (-)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: J6836_RS21105
• Protein ID: WP_219245770.1
• Coordinates: 4553955..4554323 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6836_RS21075 (J6836_21075)	4549744..4550082	+	339	WP_219245766.1	P-II family nitrogen regulator	-
J6836_RS21080 (J6836_21080)	4550093..4551373	+	1281	WP_219245767.1	ammonium transporter AmtB	-
J6836_RS21085 (J6836_21085)	4551511..4552377	-	867	WP_219245768.1	acyl-CoA thioesterase II	-
J6836_RS21090 (J6836_21090)	4552617..4553075	+	459	WP_219245769.1	YbaY family lipoprotein	-
J6836_RS21100 (J6836_21100)	4553678..4553881	-	204	WP_004905417.1	HHA domain-containing protein	Toxin
J6836_RS21105 (J6836_21105)	4553955..4554323	-	369	WP_219245770.1	Hha toxicity modulator TomB	Antitoxin
J6836_RS21110 (J6836_21110)	4554848..4556221	-	1374	WP_219245771.1	murein transglycosylase D	-
J6836_RS21115 (J6836_21115)	4556302..4557057	-	756	WP_219245772.1	hydroxyacylglutathione hydrolase	-
J6836_RS21120 (J6836_21120)	4557092..4557823	+	732	WP_219245773.1	methyltransferase domain-containing protein	-
J6836_RS21125 (J6836_21125)	4557820..4558290	-	471	WP_219245774.1	ribonuclease HI	-
J6836_RS21130 (J6836_21130)	4558345..4559109	+	765	WP_219245775.1	DNA polymerase III subunit epsilon	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-117)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8061.34 Da
• Isoelectric Point: 6.9770

>T197778 WP_004905417.1 NZ_CP072453:c4553881-4553678 [Providencia sp. R33]
MTKSDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Nucleotide

• Length: 204 bp

>T197778 NZ_CP096705:450807-451196 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 14179.07 Da
• Isoelectric Point: 4.2336

>AT197778 WP_219245770.1 NZ_CP072453:c4554323-4553955 [Providencia sp. R33]
MDEYSPKRHDIAELKYLCNSLNRDAILSLQQTNTHWINDLSSEQSAALNELIEHIAAFVWRFKIKYPKENLVISLIEEYL
DETYDLFGSPIITLSEIIDWETMNQNLVAVLDDDLKCLTSKT

Nucleotide

• Length: 369 bp

>AT197778 NZ_CP096705:450543-450800 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Structures

Toxin

• AlphaFold DB: A0A291E6Q2