Detailed information of TA system TA197775

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 2197336..2197886
• Replicon: chromosome
• Accession: NZ_CP072453
• Organism: Providencia sp. R33

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: J6836_RS10465
• Protein ID: WP_219249095.1
• Coordinates: 2197578..2197886 (+)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: J6836_RS10460
• Protein ID: WP_219249094.1
• Coordinates: 2197336..2197578 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6836_RS10435 (J6836_10440)	2192478..2192918	+	441	WP_219249087.1	flagellar export chaperone FlgN	-
J6836_RS10440 (J6836_10445)	2192950..2193270	-	321	WP_219249089.1	helix-turn-helix domain-containing protein	-
J6836_RS10445 (J6836_10450)	2193263..2193649	-	387	WP_219249091.1	type II toxin-antitoxin system RelE/ParE family toxin	-
J6836_RS10450 (J6836_10455)	2193829..2195928	-	2100	WP_219249092.1	flagellar biosynthesis protein FlhA	-
J6836_RS10455 (J6836_10460)	2195921..2197072	-	1152	WP_219249093.1	flagellar biosynthesis protein FlhB	-
J6836_RS10460 (J6836_10465)	2197336..2197578	+	243	WP_219249094.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
J6836_RS10465 (J6836_10470)	2197578..2197886	+	309	WP_219249095.1	CcdB family protein	Toxin
J6836_RS10470 (J6836_10475)	2197901..2198458	+	558	WP_219249096.1	hypothetical protein	-
J6836_RS10475 (J6836_10480)	2198466..2198765	-	300	WP_219249097.1	helix-turn-helix transcriptional regulator	-
J6836_RS10480 (J6836_10485)	2198879..2199517	-	639	WP_219249099.1	protein phosphatase CheZ	-
J6836_RS10485 (J6836_10490)	2199542..2199934	-	393	WP_206083837.1	chemotaxis response regulator CheY	-
J6836_RS10490 (J6836_10495)	2199974..2201041	-	1068	WP_219249101.1	chemotaxis response regulator protein-glutamate methylesterase	-
J6836_RS10495 (J6836_10500)	2201041..2201877	-	837	WP_219249102.1	CheR family methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-101)

Antitoxin

• Post-segregation antitoxin CcdA (10-80)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11683.65 Da
• Isoelectric Point: 6.0631

>T197775 WP_219249095.1 NZ_CP072453:2197578-2197886 [Providencia sp. R33]
MQYHLYQNRGDAIRAPYLVDIQSDIIDILNTRLVIPLYDSDLLHQPVPDKLTPCLSILGHDYILMTHLMSAVPKSLLGKE
IKNLSDERERIKKAIDLLIDGF

Nucleotide

• Length: 309 bp

>T197775 NZ_CP096702:452234-452623 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9190.72 Da
• Isoelectric Point: 9.5548

>AT197775 WP_219249094.1 NZ_CP072453:2197336-2197578 [Providencia sp. R33]
MSNLATHRIKKTVSVTVTPELYEQAKQAKLNLSAILCKALAEELKKVEAIKWKEKNIAGFNELNRISEEHGLLFDKYKEF

Nucleotide

• Length: 243 bp

>AT197775 NZ_CP096702:451970-452227 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA