Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 2192950..2193649 Replicon chromosome
Accession NZ_CP072453
Organism Providencia sp. R33

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag J6836_RS10445 Protein ID WP_219249091.1
Coordinates 2193263..2193649 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J6836_RS10440 Protein ID WP_219249089.1
Coordinates 2192950..2193270 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6836_RS10405 (J6836_10410) 2188049..2189269 - 1221 WP_219249077.1 flagellar hook protein FlgE -
J6836_RS10410 (J6836_10415) 2189299..2190150 - 852 WP_219249079.1 flagellar hook capping FlgD N-terminal domain-containing protein -
J6836_RS10415 (J6836_10420) 2190163..2190567 - 405 WP_047755990.1 flagellar basal body rod protein FlgC -
J6836_RS10420 (J6836_10425) 2190573..2190986 - 414 WP_219249081.1 flagellar basal body rod protein FlgB -
J6836_RS10425 (J6836_10430) 2191233..2191901 + 669 WP_219249083.1 flagellar basal body P-ring formation chaperone FlgA -
J6836_RS10430 (J6836_10435) 2192166..2192468 + 303 WP_219249085.1 flagellar biosynthesis anti-sigma factor FlgM -
J6836_RS10435 (J6836_10440) 2192478..2192918 + 441 WP_219249087.1 flagellar export chaperone FlgN -
J6836_RS10440 (J6836_10445) 2192950..2193270 - 321 WP_219249089.1 helix-turn-helix domain-containing protein Antitoxin
J6836_RS10445 (J6836_10450) 2193263..2193649 - 387 WP_219249091.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J6836_RS10450 (J6836_10455) 2193829..2195928 - 2100 WP_219249092.1 flagellar biosynthesis protein FlhA -
J6836_RS10455 (J6836_10460) 2195921..2197072 - 1152 WP_219249093.1 flagellar biosynthesis protein FlhB -
J6836_RS10460 (J6836_10465) 2197336..2197578 + 243 WP_219249094.1 type II toxin-antitoxin system CcdA family antitoxin -
J6836_RS10465 (J6836_10470) 2197578..2197886 + 309 WP_219249095.1 CcdB family protein -
J6836_RS10470 (J6836_10475) 2197901..2198458 + 558 WP_219249096.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-96)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14604.09 Da        Isoelectric Point: 9.9408

>T197774 WP_219249091.1 NZ_CP072453:c2193649-2193263 [Providencia sp. R33]
MAIYKTKMFNNSIKKINISDFELINAAMDVFAGQYEAHLGGGVIKKRLPLQGKGKSGGVRTLIFYRQGRHLFFADAWLKS
RLNAKGTKEIEDDTLESYKDIAKVLLQLDDEKIMKMLKANLLMEVNYE

Download         Length: 387 bp

>T197774 NZ_CP096700:448638-449027 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12087.06 Da        Isoelectric Point: 9.8397

>AT197774 WP_219249089.1 NZ_CP072453:c2193270-2192950 [Providencia sp. R33]
MNNKMNELLQFAEDMEAVGVTDDSAARRIEARIKAKELKAKFAHPKPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERGEIKPNGAALRLLTMIDERMFII

Download         Length: 321 bp

>AT197774 NZ_CP096700:448374-448631 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References