Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 878340..878934 Replicon chromosome
Accession NZ_CP072453
Organism Providencia sp. R33

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag J6836_RS04060 Protein ID WP_219247072.1
Coordinates 878340..878654 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag J6836_RS04065 Protein ID WP_219249363.1
Coordinates 878647..878934 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6836_RS04035 (J6836_04040) 874147..874404 - 258 WP_047756382.1 phosphocarrier protein Hpr -
J6836_RS04040 (J6836_04045) 874759..875712 - 954 WP_219247063.1 cysteine synthase A -
J6836_RS04045 (J6836_04050) 875944..876708 - 765 WP_219247066.1 sulfate transporter CysZ -
J6836_RS04050 (J6836_04055) 876927..877919 + 993 WP_219247068.1 cell division protein ZipA -
J6836_RS04055 (J6836_04060) 877900..878211 - 312 WP_282560602.1 hypothetical protein -
J6836_RS04060 (J6836_04065) 878340..878654 + 315 WP_219247072.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J6836_RS04065 (J6836_04070) 878647..878934 + 288 WP_219249363.1 putative addiction module antidote protein Antitoxin
J6836_RS04070 (J6836_04075) 879036..881054 + 2019 WP_219247075.1 NAD-dependent DNA ligase LigA -
J6836_RS04075 (J6836_04080) 881329..882513 + 1185 WP_219247077.1 nucleoside transporter C-terminal domain-containing protein -
J6836_RS04080 (J6836_04085) 882579..882800 + 222 WP_219247078.1 DUF3820 family protein -
J6836_RS04085 (J6836_04090) 882830..883867 - 1038 WP_255586318.1 LLM class oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Uncharacterized protein HI1420

(6-95)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11799.64 Da        Isoelectric Point: 10.1714

>T197771 WP_219247072.1 NZ_CP072453:878340-878654 [Providencia sp. R33]
MKELKQTEAFRLWESKLKDKRAKTIIAMRLFRLANGLAGDATPVGEGISELRIHHGPGYRVYFQQRGNTIILLLCGGDKS
SQSRDITLAKTLAKKWILEENNDE

Download         Length: 315 bp

>T197771 NZ_CP096694:c19135-18848 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGATATACTAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10140.58 Da        Isoelectric Point: 4.3707

>AT197771 WP_219249363.1 NZ_CP072453:878647-878934 [Providencia sp. R33]
MSNLTTYDPALALVDDDEIAFFMADAIETGDSAYIAKALGIVARAKGMSLIAAETGLSREQLYRSFSEDGNPTLKSTLAV
MKALGVELTVKTHIN

Download         Length: 288 bp

>AT197771 NZ_CP096694:c18861-18547 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References