Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 782219..782876 Replicon chromosome
Accession NZ_CP072422
Organism Klebsiella pneumoniae strain B33769

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag J6255_RS03880 Protein ID WP_002916310.1
Coordinates 782466..782876 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag J6255_RS03875 Protein ID WP_002916312.1
Coordinates 782219..782485 (+) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6255_RS03850 (J6255_03850) 777375..778808 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
J6255_RS03855 (J6255_03855) 778927..779655 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
J6255_RS03860 (J6255_03860) 779705..780016 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
J6255_RS03865 (J6255_03865) 780180..780839 + 660 WP_004889817.1 hemolysin III family protein -
J6255_RS03870 (J6255_03870) 780990..781973 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
J6255_RS03875 (J6255_03875) 782219..782485 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
J6255_RS03880 (J6255_03880) 782466..782876 + 411 WP_002916310.1 protein YgfX Toxin
J6255_RS03885 (J6255_03885) 782883..783404 - 522 WP_004144730.1 flavodoxin FldB -
J6255_RS03890 (J6255_03890) 783505..784401 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
J6255_RS03895 (J6255_03895) 784424..785137 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
J6255_RS03900 (J6255_03900) 785143..786876 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-132)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T197750 WP_002916310.1 NZ_CP072422:782466-782876 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T197750 NZ_CP096668:11918-12259 [Yersinia pestis EV76-CN]
ATGGTACTTTTTAGCCAGCGATTTGACGACTGGCTAAATGAGCAAGAAGACGCTCTTCAGGAAAAGGTTTTGGCTGATTT
GAAAAAGCTACAGGTTTACGGACCTGAGTTACCCAGGCCATATGCCGATACCGTGAAAGGTTCTCGGTACAAAAATATGA
AAGAGCTTCGCGTTCAGTTTTCTGGCCGTCCGATAAGAGCCTTTTATGCGTTCGATCCGATTCGTCGGGCTATCGTTCTT
TGTGCAGGAGATAAAAGTAATGATAAGCGGTTTTATGAAAAACTGGTGCGTATAGCTGAGGATGAATTTACAGCACATCT
GAACACACTGGAGAGCAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT197750 WP_002916312.1 NZ_CP072422:782219-782485 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT197750 NZ_CP096668:12259-12558 [Yersinia pestis EV76-CN]
ATGAGAACATTAGATGAGGTGATTGCCAGTCGTTCACCTGAAAGCCAGACACGAATTAAAGAAATGGCAGATGAGATGAT
TCTTGAGGTCGGCTTGCAGATGATGCGTGAAGAACTCCAGTTATCACAAAAACAAGTTGCTGAGGCGATGGGTATAAGCC
AGCCAGCAGTAACAAAGCTGGAGCAGCGCGGAAATGATTTAAAGCTGGCGACGTTAAAGCGTTACGTTGAAGCAATGGGA
GGCAAATTAAGCTTGGATGTTGAGCTTCCTACAGGAAGGAGAGTAGCGTTCCATGTCTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References