Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4784020..4784536 Replicon chromosome
Accession NZ_CP072413
Organism Klebsiella pneumoniae strain B32278

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag J6256_RS23335 Protein ID WP_040216106.1
Coordinates 4784020..4784304 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J6256_RS23340 Protein ID WP_064162488.1
Coordinates 4784294..4784536 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6256_RS23310 (4779437) 4779437..4779700 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
J6256_RS23315 (4779830) 4779830..4780003 + 174 WP_032425422.1 hypothetical protein -
J6256_RS23320 (4780006) 4780006..4780749 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
J6256_RS23325 (4781106) 4781106..4783244 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
J6256_RS23330 (4783552) 4783552..4784016 + 465 WP_064162487.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
J6256_RS23335 (4784020) 4784020..4784304 - 285 WP_040216106.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J6256_RS23340 (4784294) 4784294..4784536 - 243 WP_064162488.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
J6256_RS23345 (4784614) 4784614..4786524 - 1911 WP_023325426.1 PRD domain-containing protein -
J6256_RS23350 (4786547) 4786547..4787701 - 1155 WP_064162489.1 lactonase family protein -
J6256_RS23355 (4787768) 4787768..4788508 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11097.94 Da        Isoelectric Point: 10.4962

>T197745 WP_040216106.1 NZ_CP072413:c4784304-4784020 [Klebsiella pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T197745 NZ_CP096666:c1858037-1857855 [Yersinia pestis EV76-CN]
GTGAAAAGTTCGGAGCTGATAAAACTGCTCGAAACAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCCAAAAAGGATGTTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9059.57 Da        Isoelectric Point: 6.3340

>AT197745 WP_064162488.1 NZ_CP072413:c4784536-4784294 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPLKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT197745 NZ_CP096666:c1857810-1857391 [Yersinia pestis EV76-CN]
ATGGCTATCTATCCCGCCTATGTTCACGTTGATAATGATGGCTCGGCAAGCGGTTATTTCCCCGATGTCAAAGGCTGTAT
TTTTGCCATCAATGCCGGGGAGGATTTATTTGCAGAAGCATCAAGCGCCCTGGATGCACACTTTGAAGCTTTGGTGTCTG
AAGGTATCGAAATTCCTGAAGCTCATGACATGCCTTACCACGTTTACCGTAACCCATGCGATTACGCTGATGGCGGACAG
TGGTATAACGTGAATATTGATATGTCGAAATATGATGGAAAAGTTGAACGAATTAACGTCACTCTTCCGCACCGGCTGAT
TCATCAAATCGATACTATTGTTAAAGTGCGTCCCGAGTATGCCAGCCGAAGCAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References