Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4792612..4793128 Replicon chromosome
Accession NZ_CP072408
Organism Klebsiella pneumoniae strain B4650

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag J6316_RS23395 Protein ID WP_040216106.1
Coordinates 4792612..4792896 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J6316_RS23400 Protein ID WP_064162488.1
Coordinates 4792886..4793128 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6316_RS23370 (4788029) 4788029..4788292 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
J6316_RS23375 (4788422) 4788422..4788595 + 174 WP_032425422.1 hypothetical protein -
J6316_RS23380 (4788598) 4788598..4789341 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
J6316_RS23385 (4789698) 4789698..4791836 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
J6316_RS23390 (4792144) 4792144..4792608 + 465 WP_064162487.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
J6316_RS23395 (4792612) 4792612..4792896 - 285 WP_040216106.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J6316_RS23400 (4792886) 4792886..4793128 - 243 WP_064162488.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
J6316_RS23405 (4793206) 4793206..4795116 - 1911 WP_023325426.1 PRD domain-containing protein -
J6316_RS23410 (4795139) 4795139..4796293 - 1155 WP_064162489.1 lactonase family protein -
J6316_RS23415 (4796360) 4796360..4797100 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11097.94 Da        Isoelectric Point: 10.4962

>T197729 WP_040216106.1 NZ_CP072408:c4792896-4792612 [Klebsiella pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T197729 NZ_CP096664:c143848-143567 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGAGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9059.57 Da        Isoelectric Point: 6.3340

>AT197729 WP_064162488.1 NZ_CP072408:c4793128-4792886 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPLKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT197729 NZ_CP096664:c144072-143845 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGACCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References