Detailed information of TA system TA197696

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3205198..3205877
• Replicon: chromosome
• Accession: NZ_CP072398
• Organism: Acinetobacter baumannii strain KSK2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: J6B58_RS15295
• Protein ID: WP_000838146.1
• Coordinates: 3205695..3205877 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: J6B58_RS15290
• Protein ID: WP_000966688.1
• Coordinates: 3205198..3205602 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6B58_RS15280 (J6B58_15280)	3204154..3204417	-	264	WP_001275792.1	hypothetical protein	-
J6B58_RS15285 (J6B58_15285)	3204419..3205099	-	681	WP_000721572.1	hypothetical protein	-
J6B58_RS15290 (J6B58_15290)	3205198..3205602	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
J6B58_RS15295 (J6B58_15295)	3205695..3205877	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
J6B58_RS15300 (J6B58_15300)	3206203..3206718	-	516	WP_001185592.1	hypothetical protein	-
J6B58_RS15305 (J6B58_15305)	3206788..3207705	-	918	WP_000094273.1	phage tail tube protein	-
J6B58_RS15310 (J6B58_15310)	3207758..3208729	-	972	WP_032051761.1	hypothetical protein	-
J6B58_RS15315 (J6B58_15315)	3208729..3209082	-	354	WP_032051762.1	hypothetical protein	-
J6B58_RS15320 (J6B58_15320)	3209178..3209396	-	219	WP_002002228.1	hypothetical protein	-
J6B58_RS15325 (J6B58_15325)	3209398..3209796	-	399	WP_002062850.1	phage tail terminator-like protein	-
J6B58_RS15330 (J6B58_15330)	3209798..3210166	-	369	WP_001993865.1	hypothetical protein	-
J6B58_RS15335 (J6B58_15335)	3210138..3210542	-	405	WP_045544425.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3186029..3235115	49086

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T197696 WP_000838146.1 NZ_CP072398:c3205877-3205695 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T197696 NZ_CP096587:c594465-594001 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT197696 WP_000966688.1 NZ_CP072398:c3205602-3205198 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT197696 NZ_CP096587:c594800-594465 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6