Detailed information of TA system TA197695

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2222848..2224484
• Replicon: chromosome
• Accession: NZ_CP072398
• Organism: Acinetobacter baumannii strain KSK2

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A090B5R1
• Locus tag: J6B58_RS10655
• Protein ID: WP_045544121.1
• Coordinates: 2222848..2224179 (+)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: J6B58_RS10660
• Protein ID: WP_001101310.1
• Coordinates: 2224176..2224484 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6B58_RS10635 (J6B58_10635)	2219160..2220323	+	1164	WP_045544117.1	hypothetical protein	-
J6B58_RS10640 (J6B58_10640)	2220450..2221421	+	972	WP_087486613.1	5'/3'-nucleotidase SurE	-
J6B58_RS10645 (J6B58_10645)	2221433..2222077	+	645	WP_045544119.1	hypothetical protein	-
J6B58_RS10650 (J6B58_10650)	2222112..2222552	-	441	WP_045544120.1	HD domain-containing protein	-
J6B58_RS10655 (J6B58_10655)	2222848..2224179	+	1332	WP_045544121.1	HipA domain-containing protein	Toxin
J6B58_RS10660 (J6B58_10660)	2224176..2224484	+	309	WP_001101310.1	helix-turn-helix domain-containing protein	Antitoxin
J6B58_RS10665 (J6B58_10665)	2225207..2225755	+	549	WP_045544122.1	TetR/AcrR family transcriptional regulator	-
J6B58_RS10670 (J6B58_10670)	2225949..2227646	+	1698	WP_045544123.1	AAA family ATPase	-
J6B58_RS10675 (J6B58_10675)	2227651..2229276	+	1626	WP_045544124.1	ATP-dependent helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51189.29 Da
• Isoelectric Point: 4.9177

>T197695 WP_045544121.1 NZ_CP072398:2222848-2224179 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEKFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
KLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFVCEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T197695 NZ_CP096587:288646-289173 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11630.54 Da
• Isoelectric Point: 9.9701

>AT197695 WP_001101310.1 NZ_CP072398:2224176-2224484 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Nucleotide

• Length: 309 bp

>AT197695 NZ_CP096587:288373-288639 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCTGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Structures

Toxin

• AlphaFold DB: A0A090B5R1