Detailed information of TA system TA197694

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1915438..1916117
• Replicon: chromosome
• Accession: NZ_CP072398
• Organism: Acinetobacter baumannii strain KSK2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: J6B58_RS09170
• Protein ID: WP_000838146.1
• Coordinates: 1915438..1915620 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: J6B58_RS09175
• Protein ID: WP_000966688.1
• Coordinates: 1915713..1916117 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6B58_RS09130 (J6B58_09130)	1910518..1910886	+	369	WP_032016325.1	hypothetical protein	-
J6B58_RS09135 (J6B58_09135)	1910888..1911286	+	399	WP_045544022.1	phage tail terminator-like protein	-
J6B58_RS09140 (J6B58_09140)	1911288..1911506	+	219	WP_002132566.1	hypothetical protein	-
J6B58_RS09145 (J6B58_09145)	1911615..1912136	+	522	WP_002055493.1	SH3 domain-containing protein	-
J6B58_RS09150 (J6B58_09150)	1912233..1912586	+	354	WP_002055486.1	hypothetical protein	-
J6B58_RS09155 (J6B58_09155)	1912586..1913557	+	972	WP_045544023.1	hypothetical protein	-
J6B58_RS09160 (J6B58_09160)	1913610..1914527	+	918	WP_042774720.1	phage tail tube protein	-
J6B58_RS09165 (J6B58_09165)	1914597..1915112	+	516	WP_009517104.1	hypothetical protein	-
J6B58_RS09170 (J6B58_09170)	1915438..1915620	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
J6B58_RS09175 (J6B58_09175)	1915713..1916117	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
J6B58_RS09180 (J6B58_09180)	1916217..1916726	+	510	WP_000735548.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1885008..1939627	54619

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T197694 WP_000838146.1 NZ_CP072398:1915438-1915620 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T197694 NZ_CP096587:267080-267310 [Escherichia coli]
CTGGATCAGCTATTTAAATCACCTTTACCTCAAGGAATCAAATGGACTGATATAGAATCTCTGGTTAAAGCGTTAGGCGG
AGAAATTAAGGAAGGTAGGGGGTCGCGCTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGT
CGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT197694 WP_000966688.1 NZ_CP072398:1915713-1916117 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT197694 NZ_CP096587:267307-267666 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6