Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 4545412..4545773 Replicon chromosome
Accession NZ_CP072396
Organism Xanthomonas citri pv. fuscans strain 6165R(delta)tal22B

Toxin (Protein)


Gene name EcnB Uniprot ID M4UGA1
Locus tag J4T80_RS19495 Protein ID WP_005914328.1
Coordinates 4545412..4545546 (-) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID H8FG64
Locus tag J4T80_RS19500 Protein ID WP_003486606.1
Coordinates 4545621..4545773 (-) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J4T80_RS19480 (J4T80_19480) 4542441..4543484 - 1044 WP_033481136.1 MBL fold metallo-hydrolase -
J4T80_RS19485 (J4T80_19485) 4543514..4544803 - 1290 WP_022560228.1 tryptophan--tRNA ligase -
J4T80_RS19490 (J4T80_19490) 4544976..4545185 - 210 WP_016904514.1 CsbD family protein -
J4T80_RS19495 (J4T80_19495) 4545412..4545546 - 135 WP_005914328.1 entericidin A/B family lipoprotein Toxin
J4T80_RS19500 (J4T80_19500) 4545621..4545773 - 153 WP_003486606.1 entericidin A/B family lipoprotein Antitoxin
J4T80_RS19505 (J4T80_19505) 4545880..4546803 - 924 WP_007966941.1 arginase -
J4T80_RS19510 (J4T80_19510) 4547124..4547576 + 453 WP_007974175.1 roadblock/LC7 domain-containing protein -
J4T80_RS19515 (J4T80_19515) 4547640..4547999 + 360 WP_003486613.1 hypothetical protein -
J4T80_RS19520 (J4T80_19520) 4548096..4549013 + 918 WP_046832402.1 hypothetical protein -
J4T80_RS19525 (J4T80_19525) 4549010..4549552 + 543 WP_003486615.1 GTPase -
J4T80_RS19530 (J4T80_19530) 4550032..4550715 + 684 WP_007966938.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4459.32 Da        Isoelectric Point: 9.3487

>T197692 WP_005914328.1 NZ_CP072396:c4545546-4545412 [Xanthomonas citri pv. fuscans]
MKRAIVLLVLSMLSVGMLAGCNTVAGAGKDVQGAGEKVEDAARK

Download         Length: 135 bp

>T197692 NZ_CP096583:3648558-3648803 [Rhodococcus pyridinivorans]
ATGGCGAGGTCGGCTGTACGCGCCATGGCGAGGTCGTTGCCGGAGAAGGTAGCAACTGCGGTATACGAGTTCGTCACAGG
ACCCCTTCTCGAGAATCCGAAGCGGGTGGGGAAGCCGTTGAATCCGCCTCTTGCGCCGGCGTACAGCGCCCGGCGAGGTG
AATATCGCGTCCTGTATCTGATCGATGATGCGAACCGCACGGTCGAGGTCACCGCGATTTCGCACCGTGCCGATGCGTAT
CGATAG

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5122.07 Da        Isoelectric Point: 8.7942

>AT197692 WP_003486606.1 NZ_CP072396:c4545773-4545621 [Xanthomonas citri pv. fuscans]
MKRLLTLMVLGLFSAGVMTGCNTVAGAGKDMQGAGNKVEKTAEKCSDGKC

Download         Length: 153 bp

>AT197692 NZ_CP096583:3648244-3648528 [Rhodococcus pyridinivorans]
ATGACGACTCTTCCTGTTGCCGACGCGCGGGCGCAATTGTCACGACTGGTCGATGAGGCCGAGCGCACACACGAGCGATT
CGAGATCACCCGCAACGGGCACCGCGCCGCGGTGCTTCTCGGTGCCGACGATTACGACGCGATGCAGGAGACGATCGCGG
TGTTGTCGGATACGGATCTGCTGCGGGCGCACGTCGAGGGCCGAACGGAGGTCGAGTCGGGAGACGTCGTCGATGTACAG
GAATTGACGCAGCTGATGCGTGATGCTCGGTCGTCCGAGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G2W7U6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YLX6

References