Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 28254..28921 Replicon plasmid pA
Accession NZ_CP072395
Organism Xanthomonas phaseoli pv. phaseoli strain 6546R(delta)tal18H

Toxin (Protein)


Gene name vapC Uniprot ID A0A3T0G501
Locus tag J6335_RS22220 Protein ID WP_022557732.1
Coordinates 28254..28670 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U4M4Z6
Locus tag J6335_RS22225 Protein ID WP_022557731.1
Coordinates 28667..28921 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6335_RS22195 (J6335_22195) 23984..25303 + 1320 WP_022557736.1 right-handed parallel beta-helix repeat-containing protein -
J6335_RS22200 (J6335_22200) 25430..26722 + 1293 WP_033481893.1 M12 family metallo-peptidase -
J6335_RS22205 (J6335_22205) 26877..27425 + 549 WP_022557734.1 DNA topoisomerase -
J6335_RS22210 (J6335_22210) 27474..27611 + 138 Protein_27 transposase -
J6335_RS22215 (J6335_22215) 27686..28240 - 555 WP_033482006.1 plasmid pRiA4b ORF-3 family protein -
J6335_RS22220 (J6335_22220) 28254..28670 - 417 WP_022557732.1 type II toxin-antitoxin system VapC family toxin Toxin
J6335_RS22225 (J6335_22225) 28667..28921 - 255 WP_022557731.1 plasmid stability protein Antitoxin
J6335_RS22230 (J6335_22230) 29133..29726 + 594 WP_022560487.1 recombinase family protein -
J6335_RS22235 (J6335_22235) 29723..32752 + 3030 WP_022560486.1 Tn3 family transposase -
J6335_RS22240 (J6335_22240) 32785..33170 + 386 Protein_33 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - virB1 1..60281 60281
- inside IScluster/Tn - virB1 27474..45050 17576


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14833.04 Da        Isoelectric Point: 4.6812

>T197690 WP_022557732.1 NZ_CP072395:c28670-28254 [Xanthomonas phaseoli pv. phaseoli]
MIVLDTNVVSEAMKPEPHPSVRTWLNDQAAETLYLSSVTLAELLFGIAALPAGKRKDMLEQALDGLMGLFRDRVLPFDID
AARRYAELAVTAKIGGRGFPTPDGYIAAIAASRGFIVASRDTAPYEAAGVTVINPWEG

Download         Length: 417 bp

>T197690 NZ_CP096583:c2795832-2795578 [Rhodococcus pyridinivorans]
GTGAACATCACCTTCACCGACGAAGCGTGGGACGACTACCAGTTCTGGATCTCGACCGACAGAAAACAGCTCAAGCGTGT
CAACGAGCTGGTCAGGGATTGCCAACGAGACCCGTACTCGGGGATCGGCAAACCCGAACGGCTCAGACATGCCCTGTCAG
GACTGTGGTCTCGACGTATCGACAAAGAACACCGCCTGGTCTACGAGGTCATCGACGGTGCCCTGGTCATCATCGCCGCC
CGCTACCACTACTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9388.80 Da        Isoelectric Point: 8.9326

>AT197690 WP_022557731.1 NZ_CP072395:c28921-28667 [Xanthomonas phaseoli pv. phaseoli]
MAMLTVRNLPDDVHRALRMRAAQNGHSTEAEVREILATAVKPETRVRLGEALAALGRKIGLTNEDFEVFDRVRDKTPAVP
PRLE

Download         Length: 255 bp

>AT197690 NZ_CP096583:c2796077-2795829 [Rhodococcus pyridinivorans]
ATGGCTGCCATCACTGCTACCGAAGCGAGGAAAAACTTCTTTCCGCTGCTCGAACAGGTCAACAAGGACCACACCCCTGT
GGAAATCGTATCCAAGCGGGGCAATGCCGTCCTGATGTCGAAGGATGACTACGACGCCATGCTCGAGACCTCGTACCTGA
TGCAGTCTCCGGCCAACGCCCGACGACTGCTCGCCAGCATGCAGAGAGCTCGCGGAGGTGAATACACCGAAAGGGAACTC
ATCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0G501

Antitoxin

Source ID Structure
AlphaFold DB A0A3T0G545

References