Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 4451524..4451885 Replicon chromosome
Accession NZ_CP072393
Organism Xanthomonas phaseoli pv. phaseoli strain 6546R(delta)tal18H

Toxin (Protein)


Gene name EcnB Uniprot ID M4UGA1
Locus tag J6335_RS19320 Protein ID WP_005914328.1
Coordinates 4451524..4451658 (-) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID A0A3Q9Q401
Locus tag J6335_RS19325 Protein ID WP_039568455.1
Coordinates 4451733..4451885 (-) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J6335_RS19295 (J6335_19295) 4446880..4447135 + 256 Protein_3798 hypothetical protein -
J6335_RS19300 (J6335_19300) 4447216..4448442 - 1227 WP_011345585.1 IS256-like element ISXax1 family transposase -
J6335_RS19305 (J6335_19305) 4448540..4449484 - 945 WP_039568459.1 MBL fold metallo-hydrolase -
J6335_RS19310 (J6335_19310) 4449614..4450903 - 1290 WP_039568540.1 tryptophan--tRNA ligase -
J6335_RS19315 (J6335_19315) 4451085..4451294 - 210 WP_003486601.1 CsbD family protein -
J6335_RS19320 (J6335_19320) 4451524..4451658 - 135 WP_005914328.1 entericidin A/B family lipoprotein Toxin
J6335_RS19325 (J6335_19325) 4451733..4451885 - 153 WP_039568455.1 entericidin A/B family lipoprotein Antitoxin
J6335_RS19330 (J6335_19330) 4451992..4452915 - 924 WP_039568453.1 arginase -
J6335_RS19335 (J6335_19335) 4453236..4453688 + 453 WP_017158238.1 roadblock/LC7 domain-containing protein -
J6335_RS19340 (J6335_19340) 4453752..4454111 + 360 WP_003486613.1 hypothetical protein -
J6335_RS19345 (J6335_19345) 4454208..4455125 + 918 WP_103412531.1 hypothetical protein -
J6335_RS19350 (J6335_19350) 4455122..4455664 + 543 WP_039568446.1 GTPase -
J6335_RS19355 (J6335_19355) 4456133..4456816 + 684 WP_039568445.1 dTMP kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4447216..4448442 1226


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4459.32 Da        Isoelectric Point: 9.3487

>T197687 WP_005914328.1 NZ_CP072393:c4451658-4451524 [Xanthomonas phaseoli pv. phaseoli]
MKRAIVLLVLSMLSVGMLAGCNTVAGAGKDVQGAGEKVEDAARK

Download         Length: 135 bp

>T197687 NZ_CP096575:c3448115-3447726 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATAAGTCACAGAACACCGTT
TCTCGCGTCAAAATTTTAAAAATAATTGATTGTCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5138.07 Da        Isoelectric Point: 8.7942

>AT197687 WP_039568455.1 NZ_CP072393:c4451885-4451733 [Xanthomonas phaseoli pv. phaseoli]
MKRLLTLMVLGLFSSGVMTGCNTVAGAGKDMQGAGNKVEKTAEKCSDGKC

Download         Length: 153 bp

>AT197687 NZ_CP096575:c3448379-3448122 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G2W7U6

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q9Q401

References