Detailed information of TA system TA197686

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 3652115..3652665
• Replicon: chromosome
• Accession: NZ_CP072387
• Organism: Cellulosimicrobium cellulans strain ORNL-0100

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: J5A69_RS16515
• Protein ID: WP_061269405.1
• Coordinates: 3652115..3652393 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A4Y8R8B4
• Locus tag: J5A69_RS16520
• Protein ID: WP_061269406.1
• Coordinates: 3652390..3652665 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J5A69_RS16500 (J5A69_16495)	3647407..3648294	+	888	WP_211932569.1	MurR/RpiR family transcriptional regulator	-
J5A69_RS16505 (J5A69_16500)	3648291..3651224	+	2934	WP_211932570.1	FAD-binding and (Fe-S)-binding domain-containing protein	-
J5A69_RS16510 (J5A69_16505)	3651363..3651983	+	621	WP_211932571.1	M15 family metallopeptidase	-
J5A69_RS16515 (J5A69_16510)	3652115..3652393	-	279	WP_061269405.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J5A69_RS16520 (J5A69_16515)	3652390..3652665	-	276	WP_061269406.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
J5A69_RS16525 (J5A69_16520)	3653283..3656960	+	3678	WP_244985550.1	PQQ-dependent sugar dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (11-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10479.02 Da
• Isoelectric Point: 8.5812

>T197686 WP_061269405.1 NZ_CP072387:c3652393-3652115 [Cellulosimicrobium cellulans]
VTDDQTPAWRVEIAPAAERSLLRLPHKIAAAVVEFVTTTLPTNPERMSKPLRYELEGLRSARRGDYRVLFELDHDTGVLL
VVRIAHRADAYR

Nucleotide

• Length: 279 bp

>T197686 NZ_CP096575:c2354175-2353993 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10004.16 Da
• Isoelectric Point: 4.5951

>AT197686 WP_061269406.1 NZ_CP072387:c3652665-3652390 [Cellulosimicrobium cellulans]
MKSVALSEAKDKLSALVDEADREHEIIRITRHGRGAAVLMAEDDLESLRETLFWLSQPGVRDDIDEARRAAAEGATTSGE
DLRARFGLPAQ

Nucleotide

• Length: 276 bp

>AT197686 NZ_CP096575:c2353900-2353496 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Antitoxin

• AlphaFold DB: A0A4Y8R8B4