Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 1066034..1066695 Replicon chromosome
Accession NZ_CP072387
Organism Cellulosimicrobium cellulans strain ORNL-0100

Toxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J5A69_RS04585 Protein ID WP_114553343.1
Coordinates 1066034..1066447 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J5A69_RS04590 Protein ID WP_211933382.1
Coordinates 1066444..1066695 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5A69_RS04575 (J5A69_04575) 1061986..1063134 + 1149 WP_211933380.1 glycosyltransferase -
J5A69_RS04580 (J5A69_04580) 1063058..1065949 - 2892 WP_211933381.1 cation-transporting P-type ATPase -
J5A69_RS04585 (J5A69_04585) 1066034..1066447 - 414 WP_114553343.1 type II toxin-antitoxin system VapC family toxin Toxin
J5A69_RS04590 (J5A69_04590) 1066444..1066695 - 252 WP_211933382.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J5A69_RS04595 (J5A69_04595) 1066785..1067690 + 906 WP_244985664.1 RNA methyltransferase -
J5A69_RS04600 (J5A69_04600) 1067722..1068132 + 411 WP_211933384.1 hypothetical protein -
J5A69_RS04605 (J5A69_04605) 1068303..1068557 - 255 WP_211933385.1 hypothetical protein -
J5A69_RS04610 (J5A69_04610) 1068730..1069434 - 705 WP_244985665.1 alpha/beta hydrolase -
J5A69_RS04615 (J5A69_04615) 1069431..1070426 - 996 WP_211933386.1 alpha/beta fold hydrolase -
J5A69_RS04620 (J5A69_04620) 1070405..1070854 - 450 WP_021483430.1 SRPBCC family protein -
J5A69_RS04625 (J5A69_04625) 1070940..1071572 - 633 WP_076404711.1 nucleotidyltransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-62)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15070.29 Da        Isoelectric Point: 7.3191

>T197685 WP_114553343.1 NZ_CP072387:c1066447-1066034 [Cellulosimicrobium cellulans]
VRYLLDTNVVSELVRTRPDEQVVAWLRGLRTPQIYLSVLTVGEIRTGVQRLVPRDAARATALETWVHGLEETYGDRILPV
TLEIAQRWPAAHAARPLPVVESLLAATALAHGLTVATRNTRDFVDSGVPVVNPFSSP

Download         Length: 414 bp

>T197685 NZ_CP096574:c3773296-3773048 [Geomonas paludis]
ATGAGGACGAATATCATCCGTATCGGAAATTCCCAGGGAATCCGCATCCCCAAGGTTCTTCTGGAGCAAAGCCGTGTCGG
GACGGAAGTCGATGTTGAAGTAGAAGACGGCATGATCGTCATACGATCTGCATCCCGTCCGCGGGATGGATGGACAGAAA
AGTTCCGGCTTATGGCTGAACAGGGTGATGATAAGCTCGTGGACGAAGGTGTCCAGACCGAGTGGGACAAGGACGAGTGG
GAATGGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9208.37 Da        Isoelectric Point: 4.3516

>AT197685 WP_211933382.1 NZ_CP072387:c1066695-1066444 [Cellulosimicrobium cellulans]
MSWQVQDAKQRLSEVLRAAENGPQVITRHGKEIAVVVGIDLYHELAGVRVELADYLLEAPTADDLDLTRDRTPLREIDLG
ADA

Download         Length: 252 bp

>AT197685 NZ_CP096574:c3773054-3772731 [Geomonas paludis]
ATGGTAGCCAAGCGCTTCGAGGTTTATCTAGTCAACCTGGATCCGACGGTAGGGAGAGAGATTCGTAAATCCAGGCCGTG
TCTTATCATCTCCCCTGACGAAATGAACAAGTACTTGGGAACCGTGATCGTCGCCCCGATGACAACTAAGGGGAGGGATT
ATCCGACGCGGGTTTCGTGTTCCTTTCGCGGCAAGGATGGCCAAGTGGTCCTTGACCAGATCCGAACCATAGATAAATCC
CGACTGGTCGAAAAGCAGGGGCGGTTGGCAAAGGACGCTCAGGATCAGGTTCTGGCCATCCTTGCCGATATGTTCGCCCC
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References