Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 14639..15291 Replicon chromosome
Accession NZ_CP072387
Organism Cellulosimicrobium cellulans strain ORNL-0100

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J5A69_RS00055 Protein ID WP_211932917.1
Coordinates 14639..15061 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J5A69_RS00060 Protein ID WP_009863886.1
Coordinates 15058..15291 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5A69_RS00040 (J5A69_00040) 10973..12355 + 1383 WP_211932915.1 C40 family peptidase -
J5A69_RS00045 (J5A69_00045) 12426..12929 - 504 WP_034655165.1 inorganic diphosphatase -
J5A69_RS00050 (J5A69_00050) 13192..14604 + 1413 WP_211932916.1 D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase -
J5A69_RS00055 (J5A69_00055) 14639..15061 - 423 WP_211932917.1 type II toxin-antitoxin system VapC family toxin Toxin
J5A69_RS00060 (J5A69_00060) 15058..15291 - 234 WP_009863886.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
J5A69_RS00065 (J5A69_00065) 15377..16504 + 1128 WP_244985591.1 zinc-dependent metalloprotease -
J5A69_RS00070 (J5A69_00070) 16508..17608 + 1101 WP_211932918.1 tRNA lysidine(34) synthetase TilS -
J5A69_RS00075 (J5A69_00075) 17614..18168 + 555 WP_021479810.1 hypoxanthine phosphoribosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15031.16 Da        Isoelectric Point: 6.4868

>T197684 WP_211932917.1 NZ_CP072387:c15061-14639 [Cellulosimicrobium cellulans]
VSTLYLLDTNVLVALLRGHGAAARPRLREAEGRVAVSTVSKMELEYGVERSQDPARNRQAVDELLSLVDVLPFDSLAAMH
AGRVRAVLAARGTPVGPYDALLAGHARSLGLVLVTNNVREFSRVPGLEVEDWLADATHGP

Download         Length: 423 bp

>T197684 NZ_CP096574:c3773054-3772731 [Geomonas paludis]
ATGGTAGCCAAGCGCTTCGAGGTTTATCTAGTCAACCTGGATCCGACGGTAGGGAGAGAGATTCGTAAATCCAGGCCGTG
TCTTATCATCTCCCCTGACGAAATGAACAAGTACTTGGGAACCGTGATCGTCGCCCCGATGACAACTAAGGGGAGGGATT
ATCCGACGCGGGTTTCGTGTTCCTTTCGCGGCAAGGATGGCCAAGTGGTCCTTGACCAGATCCGAACCATAGATAAATCC
CGACTGGTCGAAAAGCAGGGGCGGTTGGCAAAGGACGCTCAGGATCAGGTTCTGGCCATCCTTGCCGATATGTTCGCCCC
GTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8575.63 Da        Isoelectric Point: 7.0138

>AT197684 WP_009863886.1 NZ_CP072387:c15291-15058 [Cellulosimicrobium cellulans]
MVRTTVFRSNRTQAVRLPKAVALPDDVREVDVRAIGRSRVITPAGSGWDEWFEHGLRVGPGFLADRDQGTADEREAL

Download         Length: 234 bp

>AT197684 NZ_CP096574:c3773296-3773048 [Geomonas paludis]
ATGAGGACGAATATCATCCGTATCGGAAATTCCCAGGGAATCCGCATCCCCAAGGTTCTTCTGGAGCAAAGCCGTGTCGG
GACGGAAGTCGATGTTGAAGTAGAAGACGGCATGATCGTCATACGATCTGCATCCCGTCCGCGGGATGGATGGACAGAAA
AGTTCCGGCTTATGGCTGAACAGGGTGATGATAAGCTCGTGGACGAAGGTGTCCAGACCGAGTGGGACAAGGACGAGTGG
GAATGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References